PMID: 11921116Mar 29, 2002Paper

Combination of dopamine transporter and D2 receptor SPECT in the diagnostic evaluation of PD, MSA, and PSP

Movement Disorders : Official Journal of the Movement Disorder Society
Yun J KimAnthony E Lang

Abstract

It is often difficult to differentiate clinically between Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). The objective of this work was to investigate whether combined pre- and postsynaptic dopaminergic single photon emission computed tomography (SPECT) scanning can reliably demonstrate changes in the nigrostriatal dopaminergic system and help differentiate between normal controls, PD, MSA, and PSP patients. We performed SPECT evaluation of the dopamine transporter (DAT) and dopamine D2 receptors (D2). SPECT scans using [123I]beta-CIT (for DAT) and [123I]IBF (for D2) were performed in 18 patients with PD (12 dopa-naïve and 6 on levodopa and/or dopamine agonists), 7 with MSA of the striatonigral degeneration type, 6 with PSP, and 29 normal controls. Antiparkinsonian drugs were withheld for at least 12 hours before the scans. DAT and D2 binding potentials (Rv = V3/V2) were measured for caudate, anterior, and posterior putamen on the sides ipsilateral and contralateral to the worst motor symptoms. DAT binding in the posterior putamen was markedly reduced in all patients. However, D2 binding in posterior putamen was significantly increased in dopa-untreated PD, being greater than ...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A H RajputA Rajput
Dec 1, 1990·Brain : a Journal of Neurology·J M Fearnley, A J Lees
Jan 1, 1985·Journal of Neural Transmission·M Guttman, P Seeman
Nov 1, 1985·Annals of Neurology·M RubergA Rascol
May 1, 1995·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A E Lang
Aug 1, 1994·Brain : a Journal of Neurology·G K WenningN P Quinn
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
May 1, 1994·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningN P Quinn
Sep 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·J B SchulzJ Dichgans
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R B InnisS Wang
Aug 1, 1993·Annals of Neurology·A ChurchyardG Paxinos
Jul 1, 1996·Neurology·R A Mackenzie
Nov 1, 1996·Neurology·I LitvanL Fairbanks
Jan 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·A AntoniniK L Leenders
Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningN P Quinn
Apr 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·C L Barclay, A E Lang
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·J SchwarzW H Oertel
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·W PirkerT Brücke

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Citations

Dec 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·G M KnudsenL Werdelin
Mar 26, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Randel L SwansonHoward Hurtig
Feb 1, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Diederick StoffersHenk W Berendse
Oct 21, 2006·European Journal of Nuclear Medicine and Molecular Imaging·C C P VerstappenM W I M Horstink
Jul 25, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Kenji IshibashiKenji Ishii
Jul 2, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Susanna Jakobson MoKatrine Riklund
Dec 22, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Georg GoebelChristoph Scherfler
Mar 31, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Michael NockerChristoph Scherfler
May 28, 2009·Journal of Neurology·Gregor K Wenning, Nadia Stefanova
Jun 6, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ruth DjaldettiMordechai Lorberboym
Jun 26, 2004·Current Neurology and Neuroscience Reports·Dennis J Zgaljardic, Andrew Feigin
Aug 6, 2004·European Journal of Radiology·Rahyeong JuhTasuk Suh
Jul 10, 2003·Lancet Neurology·David J Burn, Andrew J Lees
Jan 30, 2004·Lancet Neurology·Gregor K WenningWerner Poewe
Aug 4, 2011·Brain : a Journal of Neurology·Jeffrey L CummingsPaul Kemp
Mar 15, 2006·Nuclear Medicine Communications·Luca FilippiOrazio Schillaci
Mar 23, 2010·Clinical Nuclear Medicine·Paloma PifarréJoan Castell-Conesa
Sep 4, 2007·BMC Neurology·Annemarie M M VlaarWim E J Weber
Oct 23, 2009·PloS One·Krisztina K JohansenMikhail Bogdanov
Oct 29, 2013·BioMed Research International·Susanna Jakobson MoKatrine Riklund
Jan 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneMarco Salvatore
Oct 20, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Koen Van LaereJacques Darcourt
Sep 20, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Hae Won KimChong Sik Lee
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Sylvia M BoeschGregor K Wenning
Jun 16, 2009·Behavioural Brain Research·Susanne NikolausHans-Wilhelm Müller
Dec 18, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Gaetano BarbagalloPatrice Péran
Jun 3, 2008·Seminars in Nuclear Medicine·Jeffrey H Meyer
May 27, 2008·Neurobiology of Disease·Andrea PanzacchiDaniela Perani
Oct 24, 2007·Brain Research·Bhupinder SinghCaroline J Zeiss
Sep 25, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Andrew H EvansAndrew J Lees
Mar 24, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·David J BrooksUNKNOWN Neuroimaging Working Group on MSA
Mar 16, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiWerner Poewe
Aug 11, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Noriyuki KimuraToshihide Kumamoto
Jan 25, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Yun Ju Christine SongGlenda Margaret Halliday
Jan 19, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·David J Brooks
Nov 22, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Laura D Perju-DumbravaWalter Pirker
Apr 24, 2014·International Journal of Clinical Practice·P BorghammerA Morsing

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