Combination of electroporation delivered metabolic modulators with low-dose chemotherapy in osteosarcoma

Oncotarget
Kheshwant S GillPatrick F Forde

Abstract

Osteosarcoma accounts for roughly 60% of all malignant bone tumors in children and young adults. The five-year survival rate for localized tumors after surgery and chemotherapy is approximately 70% whilst it drastically reduces to 15-30% in metastatic cases. Metabolic modulation is known to increase sensitivity of cancers to chemotherapy. A novel treatment strategy in Osteosarcoma is needed to battle this devastating malady. Electroporation-delivered metabolic modulators were more effective in halting the cell cycle of Osteosarcoma cells and this negatively affects their ability to recover and proliferate, as shown in colony formation assays. Electroporation-delivered metabolic modulators increase the sensitivity of Osteosarcoma cells to chemotherapy and this combination reduces their survivability. This novel treatment approach highlights the efficacy of electroporation in the delivery of metabolic modulators in Osteosarcoma cells, and increased sensitivity to chemotherapy allowing for a lower dose to be therapeutic. Metabolic modulations of two Osteosarcoma cell lines were performed with clinically available modulators delivered using electroporation, and its combination with low-dose Cisplatin. The effects of Dicholoroacetic...Continue Reading

References

Jan 11, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M MirC Paoletti
Nov 14, 2002·Annual Review of Genetics·Kara A NybergTed A Weinert
Feb 14, 2003·Mayo Clinic Proceedings·Gennady N MachakValeria V Glebovskaya
Feb 24, 1956·Science·O WARBURG
May 29, 2004·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·José Antonio López-GuerreroAntonio Llombart-Bosch
Jun 11, 2004·Acta Orthopaedica Scandinavica. Supplementum·S SmelandT A Alvegård
Jul 22, 2004·The Oncologist·Neyssa MarinaRichard Gorlick
Sep 4, 2004·Clinical Orthopaedics and Related Research·Kenichi IsobeKunio Takaoka
Jan 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Thomas F DeLaneyHerman D Suit
Jul 13, 2006·Expert Review of Anticancer Therapy·Alexander J Chou, Richard Gorlick
Apr 7, 2007·Clinical Orthopaedics and Related Research·Timothy A DamronAndrew Stewart
Jul 7, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G SersaM Snoj
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mira SadadcharamGerald C O'sullivan
Aug 30, 2008·Paediatric Drugs·Alexander J ChouRichard Gorlick
Oct 11, 2008·Cell Death and Differentiation·G KroemerUNKNOWN Nomenclature Committee on Cell Death 2009
Mar 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mark WallaceLuwy Musey
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jul 4, 2009·The Journal of Biological Chemistry·Diansheng ZhongWei Zhou
Sep 19, 2009·Expert Opinion on Drug Delivery·Dennis P M Hughes
Jan 25, 2011·Nature Reviews. Cancer·Rob A CairnsTak W Mak
Feb 10, 2011·Nature Reviews. Urology·Toshinari YamasakiJames Brugarolas
Sep 1, 2011·Nature Reviews. Drug Discovery·Matthew G Vander Heiden
Jan 13, 2012·Cell Death & Disease·C Muñoz-PinedoJ-E Ricci
Mar 24, 2012·Cancer Cell·Patrick S Ward, Craig B Thompson
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marie BénéteauJean-Ehrland Ricci
Feb 12, 2013·Molecular Cell·Christian M Metallo, Matthew G Vander Heiden
Sep 17, 2013·Journal of Cellular Physiology·Alia AhmedFazlul H Sarkar
Dec 5, 2013·Molecular Cancer·Shanmugasundaram Ganapathy-Kanniappan, Jean-Francois H Geschwind
Dec 25, 2013·International Journal of Oncology·Angelantonio NotarangeloLeopoldo Zelante
Sep 17, 2014·Expert Opinion on Investigational Drugs·Douglas W SborovPamela J Harris
Dec 2, 2015·Experimental and Therapeutic Medicine·Tianyan WangNing Wang
Mar 8, 2016·Journal of Pediatric Hematology/oncology·Jamie C HarrisSrikumar Pillai
Jul 5, 2016·Biochimica Et Biophysica Acta·Kheshwant S GillPatrick F Forde
Feb 12, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·J Sybil BiermannJillian L Scavone

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
flow cytometry
light microscopy

Software Mentioned

EndoVe System

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Current Orthopaedic Practice
C Parker GibbsSteven C Ghivizzani
Bulletin du cancer. Radiothérapie : journal de la Société française du cancer : organe de la société française de radiothérapie oncologique
G Leverger, P Touzet
© 2022 Meta ULC. All rights reserved