Combination of exercise and calorie restriction exerts greater efficacy on cardioprotection than monotherapy in obese-insulin resistant rats through the improvement of cardiac calcium regulation

Metabolism: Clinical and Experimental
Siripong PaleeNipon Chattipakorn

Abstract

Long-term high-fat diet (HFD) consumption causes obese-insulin resistance which is known to be a major risk factor for cardiovascular diseases due to its impact on the impairment of left ventricular (LV) contractile function and cardiac mitochondrial function. Intracellular calcium [Ca2+]i regulation plays an important role in the maintenance of LV function. Although either caloric restriction (CR) or exercise (Ex) are shown to strongly affect metabolic status and LV function, the combined effects of exercise and calorie restriction on cardiometabolic status, cardiac mitochondrial dynamics and cardiac [Ca2+]i transient homeostasis under conditions of obese-insulin resistance have never been investigated. Female rats were fed with either a high-fat diet (HFD: fat, 59.28%; protein, 26.45%; carbohydrate, 14.27%) or a normal diet (fat, 19.77%; protein, 28.24%; carbohydrate, 51.99%) for 13 weeks. HFD rats were then divided into 4 groups: 1) Vehicle (HFD + Veh); 2) Calorie restriction (HFD + CR); 3) Exercise (HFD + Ex) and 4) Combined therapy (HFD + CR + Ex). After 6-week intervention, the metabolic status, heart rate variability (HRV), LV function, cardiac mitochondrial dynamics, and [Ca2+]i transients were determined. Insulin resis...Continue Reading

Citations

Dec 17, 2019·Acta Physiologica·Marina Makrecka-KukaTerje S Larsen
Apr 11, 2020·Minerva pediatrica·Veronica M TagiFrancesco Chiarelli
Dec 20, 2020·International Journal of Molecular Sciences·Yi Sun, Shuzhe Ding
May 15, 2021·Aging·Chanisa ThonusinNipon Chattipakorn

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.