Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Bowei ZhangYuesheng Dong

Abstract

The combined effect of Oroxylum indicum seed extracts (OISE) or major flavonoids from OISE and acarbose on reducing postprandial blood glucose (PBG) levels was investigated in vitro and in vivo. In vitro, the IC50values of OISE and baicalein against α-glucosidase were 43.4±0.731μgmL-1and 25.9±0.412μgmL-1respectively. A combination of acarbose with OISE or baicalein synergistically inhibited rat intestinal α-glucosidase. The combination index (CI) values for acarbose with OISE ranged from 0.33 to 0.75, suggesting a synergistic but not additive effect. OISE was determined to be a non-competitive inhibitor of maltose-hydrolyzing activity. In vivo, OISE were administered to normoglycemic and diabetic mice, either alone or in combination with acarbose. At doses between 50 and 200mgkg-1, OISE enhanced the efficacy of acarbose by up to 5-fold. These results demonstrated that OISE enhances the efficacy of acarbose in vivo, and that the combination of OISE and acarbose displayed a synergistic effect in vitro. Therefore, OISE can be used to design dietary supplements to treat diabetes.

Citations

Feb 6, 2020·Pharmacological Reports : PR·Penghua FangZhenwen Zhang
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuesheng DongChunshan Quan
May 11, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Mst Marium BegumA H M Rahmatullah Imon
Dec 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nik Nur Hakimah Nik SallehSuat Cheng Tan
Sep 7, 2017·Journal of Agricultural and Food Chemistry·Bo-Wei ZhangYue-Sheng Dong

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