Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormone deficiency

Journal of Medicinal Food
Shirin HooshmandB H Arjmandi

Abstract

We have reported that soy isoflavones are capable of preventing loss of bone mineral density (BMD) in rats due to ovariectomy. The intestinal microflora is important in rendering soy isoflavones bioavailability by facilitating their conversion to equol. Hence, substances that can modulate the intestinal microflora could affect the bioavailability of isoflavones. The purpose of this study was to examine whether combination of genistin and fructooligosaccharides (FOS), a prebiotic, can enhance the effects of soy isoflavones on bone in ovariectomized (OVX) female rats. Forty-eight 90-day-old female Sprague-Dawley rats were either sham-operated (Sham; one group) or Ovx (three groups) and were placed on dietary treatment for 50 days. The Sham and one Ovx group received a control diet, and the remaining Ovx groups received genistin-rich isoflavones diet (Ovx+G) or genistin-rich isoflavones and FOS diet (Ovx+G+FOS). After 50 days, blood and bone specimens were collected for analysis. The genistin-rich isoflavones diet was able to significantly increase the whole-body, right femur, and fourth lumbar BMD by 1.6%, 1.48%, and 1.3%, respectively in comparison with the Ovx control. The combination of genistin-rich isoflavones diet and 5% FO...Continue Reading

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Citations

Oct 17, 2017·Pharmacological Reports : PR·Beata NowakAdam Szeląg
Jul 1, 2017·Journal of Industrial Microbiology & Biotechnology·Ruizhi HanYe Ni
May 1, 2020·Microbiology and Molecular Biology Reviews : MMBR·Feng ZhangWei Zhao
Apr 8, 2020·Archives of Pharmacal Research·Anowarul IslamMd Rashedunnabi Akanda
Aug 11, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Konica PorwalNaibedya Chattopadhyay

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

GraphPad
GraphPad Instant

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