Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure

European Heart Journal
T Dormans, P G Gerlag

Abstract

We studied the synergism between high-dose furosemide and hydrochlorothiazide in patients with severe congestive heart failure and impaired renal function showing diuretic resistance to a daily dose of furosemide of at least 250 mg. An open study. A general hospital in The Netherlands. In 20 patients with severe congestive heart failure (stage III-IV according to the New York Heart Association) with an oedematous mass of more than 5 kg and a proven diuretic resistance to high-dose furosemide, hydrochlorothiazide (25-100 mg daily) was added to the medication for 3-12 days, leaving the other medication unchanged. After correction of the hydration state, hydrochlorothiazide was withdrawn. Variables included body weight, serum electrolytes, renal function and natriuresis. Addition of hydrochlorothiazide resulted in a mean (+/-standard deviation) body weight reduction of 6.7 +/- 3.3 kg per patient. Mean daily urine volume increased from 1899 +/- 958 ml to 3065 +/- 925 ml (P < 0.001). Fractional sodium excretion increased significantly from 3.5 +/- 3.2% to 11.5 +/- 9.0% (P < 0.001). The most important side effect of this combination therapy appeared to be hypokalaemia. Mean endogenous creatinine clearance decreased (not significantly...Continue Reading

Citations

May 11, 2006·Current Heart Failure Reports·Srinivas Iyengar, William T Abraham
Sep 3, 2009·Current Heart Failure Reports·Jack F Price, Stuart L Goldstein
Jun 27, 2002·Journal of the American College of Cardiology·Paul R KalraStefan D Anker
Feb 15, 2008·Critical Care Medicine·Kelly V LiangMargaret M Redfield
Apr 15, 2004·Postgraduate Medical Journal·S U ShahW A Littler
Jun 5, 2003·Postgraduate Medical Journal·L K M De Bruyne
Aug 30, 2008·Current Heart Failure Reports·Jason A Goebel, Adrian B Van Bakel
Jun 19, 2013·Medicina clínica·Joan Carles TrullàsUNKNOWN en representación del Grupo de Trabajo de Insuficiencia Cardiaca y Fibrilación Auricular de la Sociedad Española de Medicina
Aug 29, 2012·Revista Española De Cardiología·Donald S Silverberg, Dov Wexler
Dec 21, 2012·Kidney International·Joseph F GnanarajJai Radhakrishnan
Feb 12, 2010·Kidney International·Juan A Oliver, Elizabeth C Verna
Feb 1, 2000·The American Journal of the Medical Sciences·A Greenberg
May 13, 1999·The American Journal of Medicine·B K KrämerG A Riegger
Sep 2, 2008·Heart Failure Clinics·Domenic A Sica
Aug 19, 2003·Pharmacotherapy·Brian F McBride, C Michael White
Dec 17, 2008·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Tariq Khan, J Thomas Heywood
Jan 7, 2011·Journal of Clinical Pharmacology·Zhong WangYongyan Wang
Feb 26, 2015·Cardiovascular Therapeutics·Michael P MoranvilleJonathan D Rich
Oct 30, 2010·Journal of the American College of Cardiology·Jacob C JentzerAdrian F Hernandez
Mar 30, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Tien M H NgUri Elkayam
Aug 26, 2014·British Journal of Hospital Medicine·Javed Iqbal, Muhammad M Javaid
Oct 7, 2009·Future Cardiology·Theresa A McDonagh
May 10, 2017·International Journal of Emergency Medicine·Andrew DoeringSean P Collins
Sep 17, 2016·F1000Research·Joseph Gnanaraj, Jai Radhakrishnan
Dec 8, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeffrey J CiesRobert W Mason
May 17, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·P BanerjeeL Williams
Jul 22, 2017·Therapeutic Advances in Cardiovascular Disease·Niel ShahTimothy J Vittorio
Jun 6, 2020·Pharmacology Research & Perspectives·Xiandu LuoYanqing Wu
Apr 14, 2020·Cardiology in Review·Rubayat RahmanKenneth Nugent
Feb 24, 2021·European Heart Journal. Acute Cardiovascular Care·Gregorio TersalviWilfried Mullens
Jul 23, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Rafael de la EspriellaJulio Núñez

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