Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis

Tissue Antigens
K TsuchiyaT Sasazuki

Abstract

Two hundred and four unrelated Japanese patients with rheumatoid arthritis (RA) were typed for HLA by serological typing and DNA typing. The serological typing revealed that frequencies of HLA-A11, DR4, DR53 and DQ4 were increased and those of DR8 and DQ1 were decreased in the patients. The DNA typing has precisely defined the disease-associated HLA class II alleles; DRBl*0405, DQAl*03 and DQBl*0401 showed positive associations, while negative associations were found with DRBl*0803, DQAl*0103 and DQBl*0601. The risk for RA was found to be closely associated with particular amino acid sequences of DR-beta chain, including glycine residue at the 86th position in addition to those between 70 and 74, which are known to confer binding specificity and affinity to antigenic peptides. The observation that the frequency of HLA-A11 was increased in the DRBl*0405-positive patients suggested the interaction of these two alleles in the susceptibility to RA. On the other hand, the frequency of DPB1*0201 was increased in the DRBl*0405-negative patients and the frequency of HLA-A2 was increased in the DPBl*0201-positive patients, especially in the younger onset group. These findings suggested that the combination of HLA-A2 and DPBl*0201 may co...Continue Reading

References

Feb 1, 1978·American Journal of Clinical Pathology·P I TerasakiY Iwaki
Apr 20, 1978·The New England Journal of Medicine·P Stastny
Mar 1, 1992·Tissue Antigens·R P DongT Sasazuki
Nov 1, 1992·Human Immunology·R P DongT Sasazuki
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaT Spies
Jun 1, 1989·The Journal of Experimental Medicine·Y WatanabeT Juji
May 20, 1988·Science·J A ToddL Steinman
Jan 1, 1983·Arthritis and Rheumatism·O FørreE Thorsby
Jan 1, 1983·Immunological Reviews·T SasazukiN Ohta
Apr 11, 2001·Human Immunology·S G MarshP I Terasaki
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Jun 25, 1949·Journal of the American Medical Association·O STEINBROCKERR C BATTERMAN

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Citations

Dec 24, 2010·Journal of Human Genetics·Masakatsu YanagimachiShumpei Yokota
Feb 21, 2007·Expert Opinion on Biological Therapy·Ivo Van WalleIgnace Lasters
Jun 15, 2011·European Journal of Cell Biology·Barbara Uchanska-ZieglerAndreas Ziegler
Apr 9, 2008·Journal of the American Academy of Dermatology·Mittra ErenSabine A Eming
Apr 26, 2006·Journal of Clinical Periodontology·Stefan ReichertJamal Stein
Jun 12, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A PavlovaJ Oldenburg
Mar 3, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rie TanakaToshikatsu Kaburaki
Dec 17, 2002·Blood Cells, Molecules & Diseases·James C BartonRonald T Acton
Aug 28, 2021·Clinical and Experimental Dental Research·Matti MauramoTuomas Waltimo

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