Combination of inflammatory score/liver function and AFP improves the diagnostic accuracy of HBV-related hepatocellular carcinoma

Cancer Medicine
Yezhou DingHui Wang

Abstract

Alpha-fetoprotein (AFP), routinely used for diagnosis of hepatocellular carcinoma (HCC), is limited with relatively low sensitivity and high false positivity in HBV-related HCC (HBV-HCC). Thus, an alternative approach was explored to improve specificity/sensitivity for diagnosis of HBV-HCC, using the combination of AFP, inflammatory score, and liver function. Chronic hepatitis B (CHB) (n = 510) and HBV-HCC (n = 473) patients were identified retrospectively for this study. The diagnostic value of single vs combined biomarkers for HBV-HCC was analyzed, using ROC curve. It was observed that elderliness, male sex, cirrhosis, HBeAg+ or no-antiviral therapy, and elevation of ALT, AST, neutrophil-lymphocyte ratio (NLR), and AFP were associated with developing HBV-HCC. However, the cut-off ALT defined by Chinese standard, but not by AASLD, was a risk factor. Interestingly, AFP of HBeAg- HBV-HCC patients without cirrhosis was significantly higher than that of the HBeAg+ patients. AUC values for AFP, ALT, AST, or NLR were 0.84 (95% CI: 0.815-0.862), 0.533 (95% CI: 0.501-0.565), 0.696 (95% CI: 0.666-0.725), or 0.684 (95% CI: 0.654-0.713) with optimal cut-off at 7.21 ng/mL, 43 IU/mL, 38 IU/mL, or 2.61, respectively. Combination of AFP with...Continue Reading

References

Jan 25, 2006·International Journal of Cancer. Journal International Du Cancer·Robert SurukiSherri O Stuver
Oct 2, 2009·Journal of Gastroenterology and Hepatology·Kwang Gyun LeeHo Sang Ryu
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kyu Sik JungKwang-Hyub Han
Jun 28, 2011·Gastroenterology·Chuen-Fei ChenUNKNOWN Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer in HBV (REVEAL–HBV) Study Group
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
Jan 25, 2013·Nature Reviews. Cancer·Alla ArzumanyanMark A Feitelson
Feb 26, 2013·Journal of Gastroenterology and Hepatology·Takahiro TanakaTetsuji Takayama
May 7, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Min ChenHong Tu
Aug 21, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiaoyan YiYixi Bao
Nov 28, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Roongruedee ChaiteerakijLewis R Roberts
Mar 4, 2014·International Journal of Epidemiology·Setor K KunutsorJohn Walley
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Jun 18, 2014·Annals of Internal Medicine·Devan KansagaraJanice H Jou
Jan 18, 2015·Journal of Hepatology·George V PapatheodoridisPietro Lampertico
Oct 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Omair AtiqAmit G Singal
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong
Apr 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jorge A MarreroJulie K Heimbach
Apr 22, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bo LiJianru Xiao
Oct 28, 2018·Gastroenterology·Laura Kulik, Hashem B El-Serag
Dec 21, 2018·European Journal of Epidemiology·Jesse FestBruno H Stricker
Mar 9, 2019·Seminars in Liver Disease·Franco TrevisaniAndrea Neri
Mar 30, 2019·International Journal of Cancer. Journal International Du Cancer·Jesse FestCasper H J van Eijck
Apr 11, 2019·The New England Journal of Medicine·Augusto Villanueva
Apr 16, 2019·Gastroenterology·Fasiha Kanwal, Amit G Singal

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

MedCalc
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Yan-Feng PanZu-Jiang Yu
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Chien-Hung ChenJin-Chuan Sheu
© 2021 Meta ULC. All rights reserved