Combination of intensive chemotherapy and anticancer vaccines in the treatment of human malignancies: the hematological experience.

Journal of Biomedicine & Biotechnology
Knut LisethOystein Bruserud

Abstract

In vitro studies have demonstrated that cancer-specific T cell cytotoxicity can be induced both ex vivo and in vivo, but this therapeutic strategy should probably be used as an integrated part of a cancer treatment regimen. Initial chemotherapy should be administered to reduce the cancer cell burden and disease-induced immune defects. This could be followed by autologous stem cell transplantation that is a safe procedure including both high-dose disease-directed chemotherapy and the possibility for ex vivo enrichment of the immunocompetent graft cells. The most intensive conventional chemotherapy and stem cell transplantation are used especially in the treatment of aggressive hematologic malignancies; both strategies induce T cell defects that may last for several months but cancer-specific T cell reactivity is maintained after both procedures. Enhancement of anticancer T cell cytotoxicity is possible but posttransplant vaccination therapy should probably be combined with optimalisation of immunoregulatory networks. Such combinatory regimens should be suitable for patients with aggressive hematological malignancies and probably also for other cancer patients.

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Citations

Oct 27, 2010·Cancer Immunology, Immunotherapy : CII·Rupal Ramakrishnan, Dmitry I Gabrilovich
Oct 12, 2012·Cancer Chemotherapy and Pharmacology·Oystein BruserudKimberley Joanne Hatfield
Apr 27, 2011·Cancer Immunology, Immunotherapy : CII·Evelien L J SmitsBarbara-Ann Guinn
Jun 25, 2014·Expert Opinion on Therapeutic Targets·Håkon ReikvamØystein Bruserud
Jan 3, 2015·Expert Opinion on Biological Therapy·Cheryl Lai-Lai ChiangLana E Kandalaft
Jun 19, 2015·Journal of Theoretical Biology·Mark Robertson-TessiAlain Goriely
Jun 2, 2011·Journal of Biomedicine & Biotechnology·Håkon ReikvamØystein Bruserud
Mar 29, 2014·Frontiers in Immunology·Kevin H Toomer, Zhibin Chen
Aug 5, 2015·Pharmacological Reviews·Sébastien AnguilleZwi N Berneman
Sep 24, 2011·Expert Review of Hematology·Guro Kristin MelveOystein Bruserud
Sep 4, 2012·Cancer Research·Rupal RamakrishnanDmitry I Gabrilovich

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Methods Mentioned

BETA
flow cytometry
MDS
transfection

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