Combination of Intravesical Chemotherapy and Bacillus Calmette-Guerin Versus Bacillus Calmette-Guerin Monotherapy in Intermediate- and High-risk Nonmuscle Invasive Bladder Cancer: A Systematic Review and Meta-analysis

Medicine
Jianfeng CuiBenkang Shi

Abstract

Urothelial carcinoma of the bladder has become a major cause of morbidity, mortality, and health-related costs. There is still no standard instillation therapy against bladder cancer. A meta-analysis was conducted to evaluate the efficacy and toxicity of adding chemotherapy to Bacillus Calmette-Guerin (BCG) in intermediate- and high-risk nonmuscle invasive bladder cancer (NMIBC).All randomized controlled trials (RCTs) that evaluated the efficacy of combination therapy and BCG monotherapy for intermediate- and high-risk NMIBC were comprehensively searched. Relevant databases, including PubMed, Embase, Cochrane Central Register of Controlled trials databases, and American Society of Clinical Oncology (http://www.asco.org/ASCO), the clinical trial registration website (ClinicalTrials.gov), and relevant trials from the references of selected studies were searched from initial state up to June 6, 2015. Random-effects model was used to estimate hazard ratios (HRs) statistics. All statistical analyses were performed by STATA (version 13.0, College Station, TX).Seven studies, including 1373 patients with intermediate- and high-risk NMIBC, were identified. For disease-free survival, the pooled HRs from all studies was 0.69 (95% confiden...Continue Reading

Associated Clinical Trials

References

Oct 31, 2002·Statistics in Medicine·Paula R WilliamsonAnthony G Marson
Jun 30, 2006·Contemporary Clinical Trials·Rebecca DerSimonian, Raghu Kacker
Dec 14, 2007·The Journal of Urology·Alan M NiederDavid J Lee
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Aug 16, 2017·Journal for Immunotherapy of Cancer·Ashish M KamatJonathan E Rosenberg
Apr 3, 2020·Current Opinion in Urology·José D SubielaJoan Palou
Jan 18, 2019·Medicine·Jun ZhouChaozhao Liang
May 13, 2020·Cancers·Mikołaj WołącewiczPaulina Niedźwiedzka-Rystwej
Mar 26, 2021·European Urology Focus·Ekaterina LaukhtinaUNKNOWN European Association of Urology-Young Academic Urologists (EAU-YAU): Urothelial carcinoma working group
Jun 10, 2021·Immunity·Geetika Bajpai, Matthias Nahrendorf

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Methods Mentioned

BETA
biopsies

Software Mentioned

STATA
GRADEprofiler

Related Concepts

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