Combination of Isoflurane and Propofol as General Anesthesia During Orthopedic Surgery of Perioperative Cerebral Hypoperfusion Rats to Avoid Cognitive Impairment

Frontiers in Medicine
Xinyue BuGuolin Wang

Abstract

Background: Perioperative cerebral hypoperfusion (CH) is common, although the underlying mechanism of cognitive impairment that results due to perioperative cerebral hypoperfusion remains to be determined. Isoflurane anesthesia induces neuronal injury via endoplasmic reticulum (ER) stress, whereas a sub-anesthetic dose of propofol improves postoperative cognitive function. However, the effects of the combination of isoflurane plus propofol, which is a common aesthetic combination administered to patients, on ER stress and cognition remain unknown. Methods: We sought to determine the effects of isoflurane plus propofol on ER stress and cognitive function in rats insulted by cerebral hypoperfusion. Ligation of the bilateral common carotid arteries (CCA) was adopted to develop the cerebral hypoperfusion rat model. A second surgery, open reduction and internal fixation (ORIF), requiring general anesthesia, was performed 30 days later so that the effects of anesthetics on the cognitive function of CH rats could be assessed. Rats received isoflurane alone (1.9%), propofol alone (40 mg·kg-1·h-1) or a combination of isoflurane and propofol (1% and 20 mg·kg-1·h-1 or 1.4% and 10 mg·kg-1·h-1). Behavioral studies (contextual fear condition...Continue Reading

References

Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·H Braak, E Braak
Nov 25, 2003·Anesthesia and Analgesia·Helene G LogginidouArthur J Cronin
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Sep 24, 2004·Therapeutic Drug Monitoring·Gerald ZernigAlois Saria
Nov 18, 2005·Neurobiology of Aging·Stephen W ScheffElliott J Mufson
Aug 29, 2006·Cell and Tissue Research·H Möhler
Sep 7, 2006·Journal of Cardiovascular Pharmacology·Yan Xiao-HongYuan Wen-Jun
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fabio PibiriGraziano Pinna
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Niccolò TerrandoMervyn Maze
Sep 23, 2011·Journal of Neuropathology and Experimental Neurology·Gang XuHannah C Kinney
Oct 19, 2011·Biophysical Journal·Dan WillenbringPei Tang
Jan 19, 2012·Nature Reviews. Molecular Cell Biology·Claudio Hetz
Apr 24, 2012·The International Journal of Neuroscience·Hui Liu, Junjian Zhang
Aug 29, 2012·Journal of the Neurological Sciences·Vida DemarinVanja Bašić Kes
Jun 4, 2013·Neuroscience and Biobehavioral Reviews·Xue-Li ChangMing Liu
Nov 10, 2013·Biological Psychiatry·Daniel E GlennMichelle G Craske
Jun 26, 2014·Neurochemical Research·Likui WangYuxian Shen
Sep 11, 2014·British Journal of Anaesthesia·G A MashourM S Avidan
Oct 30, 2014·Cellular and Molecular Neurobiology·Yang Zhao, Cheng-Xin Gong
Feb 5, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Junfeng ZhangZhiyi Zuo
Apr 4, 2015·Journal of the American Geriatrics Society·UNKNOWN AGS/NIA Delirium Conference Writing Group, Planning Committee and Faculty
Apr 11, 2015·Biochimica Et Biophysica Acta·Sandra I MotaAna Cristina Rego
Apr 3, 2016·Brain Research·Navit Ogen-ShternGerardo Z Lederkremer
Nov 14, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Hochang B LeeEsther S Oh
Jul 22, 2017·Nature Reviews. Neurology·Claudio Hetz, Smita Saxena

❮ Previous
Next ❯

Methods Mentioned

BETA
protein-folding
light microscopy
protein assay
electrophoresis

Software Mentioned

Maze Video Tracking System
ANY
SPSS
Image Pro Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.