Combination of low free testosterone and low vitamin D predicts mortality in older men referred for coronary angiography

Clinical Endocrinology
Elisabeth LerchbaumWinfried März

Abstract

Low levels of 25-hydroxyvitamin D [25(OH)D] and free testosterone (FT) are both associated with increased mortality. Experimental studies show a complex interplay of vitamin D and androgen metabolism suggesting that a deficiency of both hormones may be associated with a particularly adverse clinical outcome. To evaluate the impact of parallel FT and 25(OH)D deficiency in a large cohort of older men. We measured total testosterone (TT), sex hormone-binding globulin and 25(OH)D levels in 2069 men who were routinely referred for coronary angiography (1997-2000). Cox proportional hazard ratios (HRs) (with 95% confidence intervals) for mortality from all causes, cardiovascular and noncardiovascular causes according to combined deficiency of FT and 25(OH)D. In multivariate-adjusted analyses, we found an increased risk for all-cause mortality, cardiovascular and noncardiovascular mortality for men in the lowest FT [HR 1·26 (1·03-1·54), 1·24 (0·96-1·60) and 1·39 (1·00-1·93), respectively] and 25(OH)D quartile [HR 1·77 (1·47-2·13), 1·65 (1·29-2·10) and 1·89 (1·38-2·60) respectively] compared with men in higher FT and 25(OH)D quartiles. There was no independent association of TT levels with mortality. Multivariate-adjusted HRs progressiv...Continue Reading

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Citations

Nov 1, 2013·Archives of Toxicology·Stefan PilzWinfried März
Jul 6, 2014·Maturitas·Elisabeth Lerchbaum
Jul 1, 2015·Sexual Medicine Reviews·Michael Kirby
Sep 24, 2015·Andrologia·F Comhaire, A Mahmoud
Jul 22, 2014·Clinical Endocrinology·Vakkat Muraleedharan, T Hugh Jones
Jul 22, 2014·Andrology·E LerchbaumB Obermayer-Pietsch
Jan 6, 2015·Clinical Endocrinology·Annemieke C HeijboerPaul Lips
Dec 17, 2014·Ageing Research Reviews·Hui-Hui Liu, Jian-Jun Li
Feb 6, 2015·Asian Journal of Andrology·Kathleen Hwang, Martin Miner
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Oct 7, 2018·American Journal of Reproductive Immunology : AJRI·Li WuYu Sheng Liu
Sep 25, 2017·The Journal of Clinical Endocrinology and Metabolism·Elisabeth LerchbaumBarbara Obermayer-Pietsch
Apr 1, 2017·Current Cardiology Reports·Ahmed ElsherbinyHari Kumar Dandapantula
Nov 22, 2018·European Journal of Nutrition·Elisabeth LerchbaumBarbara Obermayer-Pietsch
Nov 6, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rita C TostesJane F Reckelhoff
Jun 3, 2021·Current Issues in Molecular Biology·Zoltán FontányiSzabolcs Várbíró

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