PMID: 2107117Jan 1, 1990Paper

Combination of midazolam and flumazenil in upper gastrointestinal endoscopy, a doubleblind randomized study

Gastrointestinal Endoscopy
M T Rosario, N F Costa

Abstract

We evaluated the clinical usefulness of flumazenil (formerly Ro15-1788), a benzodiazepine antagonist, in combination with midazolam in upper gastrointestinal endoscopy. Thirty outpatients were randomized into two groups: those receiving flumazenil and those receiving placebo after endoscopy. For sedation, only midazolam was used. Performances pre-sedation and post-sedation (at 30 and 60 min) were analyzed using the Trieger test, Number Connection test, and Digit Symbol test. Patients receiving flumazenil were fully alert and able to ambulate 5 min after injection with this medication. Performances at 30 min in the Trieger, Number Connection, and Digit Symbol tests were significantly better in the group receiving flumazenil, p less than 0.005, p less than 0.025, and p less than 0.01, respectively. No phlebitis, nausea, vomiting, or anxiety were noted. No resedation events were documented. We conclude that flumazenil can dramatically shorten the recovery period following sedation with midazolam in upper gastrointestinal endoscopy, and its use is not associated with major side effects.

References

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Citations

Jul 2, 2004·Gastrointestinal Endoscopy·David J BjorkmanGinger Guest-Warnick
Sep 1, 1992·Gastrointestinal Endoscopy·I RaijmanA Glombicki
Feb 23, 1999·The British Journal of Surgery·A G HeriotD Kumar
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·R F McCloy
Oct 23, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·C R Chudnofsky
Feb 25, 2014·Digestive Diseases and Sciences·Elisabeth M H Mathus-VliegenHedwig A Kos-Foekema
May 6, 1999·Gastrointestinal Endoscopy·A C ChangY K Chen
Mar 4, 2000·Gastrointestinal Endoscopy·R T WilleJ L Barnett
Jul 4, 2016·Gastrointestinal Endoscopy Clinics of North America·Joseph J Vicari
Jul 4, 2009·The American Journal of Gastroenterology·John J Vargo
Aug 16, 2002·Gastrointestinal Endoscopy Clinics of North America·Joseph J Vicari

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