Combination of multimodal imaging and molecular genetic information to investigate complex psychiatric disorders

Pharmacopsychiatry
J Gallinat, A Heinz

Abstract

Multimodal imaging, the combination of several brain imaging techniques in one subject, provides a wealth of parameters and favours the interpretation of complex models in schizophrenia research. Moreover, new imaging tools allow the investigation of distinct neurotransmitter systems and their modulation by pharmacological intervention. An important feature of multimodal imaging is the possibility to characterize the activation dependencies of different neurotransmitters and provide the experimental tool to test system models of brain function and dysfunction. The combination of measurement techniques with high temporal resolution (e. g. MEG, EEG) and high spatial resolution (e. g. fMRI) facilitate the understanding of local and global systems as well as time characteristics. Moreover, the association of imaging parameters with genetic variations of neurotransmitter systems allows the investigation of neurotransmitter activity and its role in the pathophysiology of schizophrenia. To overcome the limitations of standard statistical methods, new approaches in machine learning have to be adapted to handle multiple parameters obtained from brain imaging and genetic measurements.

Citations

Mar 12, 2008·Annals of Biomedical Engineering·Andreas WindemuthGualberto Ruaño
Jan 14, 2009·Biomedical Engineering Online·Manuchehr SoleimaniCathryn N Mitchell
Jun 4, 2008·Neuro-degenerative Diseases·J GallinatA Heinz
Oct 3, 2006·Current Opinion in Psychiatry·Paolo Fusar-Poli, Matthew R Broome
Jan 16, 2007·Neuroscience and Biobehavioral Reviews·Paolo Fusar-PoliPhilip McGuire
Sep 13, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Maryam RavanAhmad Khodayari-Rostamabad
Nov 3, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ahmad Khodayari-RostamabadHubert de Bruin

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