Combination of Multiparametric Magnetic Resonance Imaging With Elastic-fusion Biopsy Has a High Sensitivity in Detecting Clinically Significant Prostate Cancer in Daily Practice.

Clinical Genitourinary Cancer
Sara CecchiniElena Ravasi

Abstract

The index lesion (IL) is the largest cancer focus, usually harbors the highest grade, and might drive the history of prostate cancer (PCA). Multiparametric magnetic resonance imaging (mp-MRI) has a high negative predictive value in ruling out clinically significant (cs)PCA. We aimed evaluating the efficiency of mp-MRI and targeted biopsy in detecting csPCA and the concordance between the MRI index lesion (MRI-IL) and the presence of csPCA inside it. We retrospectively evaluated 158 men who underwent prostate biopsy after a positive pre-biopsy mp-MRI scan. All mp-MRI lesions were biopsied using a transrectal ultrasound elastic-fusion approach (2-4 targeted plus 10-12 random systematic biopsies). csPCA was defined as grading group ≥ 2 or > 3 cores with cancer or ≥ 50% of core involved by tumor. mp-MRI detected 158 ILs and 46 non-ILs. One hundred were Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2) score 3, 84 score 4, and 20 score 5. csPCA was found in 63.9% of the MRI-ILs. Eighty percent of detected cancer using mp-MRI and targeted biopsy was clinically significant. Eighty-seven percent of the transitional zone lesions were clinically non-significant or negative for cancer. The probability of detecting csPCA in...Continue Reading

References

Oct 23, 2009·The New England Journal of Medicine·Hashim Uddin Ahmed
Apr 26, 2012·The American Journal of Surgical Pathology·Hillary M RossJonathan I Epstein
Nov 3, 2012·The Lancet Oncology·Hashim Uddin AhmedMark Emberton
Nov 19, 2013·Urologic Oncology·Geoffrey A SonnLeonard S Marks
Oct 5, 2014·European Urology·Ian A DonaldsonHashim U Ahmed
Jul 9, 2016·Journal of Magnetic Resonance Imaging : JMRI·Matthew D GreerBaris Turkbey
Aug 14, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FerlayF Bray
Dec 5, 2018·European Urology·David C JohnsonRobert E Reiter
Dec 20, 2018·Histopathology·Andres Matoso, Jonathan I Epstein
Aug 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Thais C MussiRonaldo H Baroni

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Citations

May 20, 2021·Prostate Cancer and Prostatic Diseases·Marco DellabellaDaniele Castellani

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