Combination of N-acetylcysteine and metformin improves histological steatosis and fibrosis in patients with non-alcoholic steatohepatitis

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Claudia Pinto Marques Souza de OliveiraFlair José Carrilho

Abstract

There is no proven medical therapy for the treatment of non-alcoholic steatohepatitis (NASH). Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. The aim of our study was to evaluate the efficacy of N-acetylcysteine (NAC) in combination with metformin (MTF) in improving the aminotransferases and histological parameters (steatosis, inflammation, hepatocellular ballooning, and fibrosis) after 12 months of treatment. Twenty consecutive patients (mean age 53 +/- 2 years [36-68] and body mass index [BMI] 29 [25-35]) with biopsy-proven NASH were enrolled in the study. NAC (1.2 g/day) and MTF (850-1000 mg/day) were given orally for 12 months. All patients underwent evaluation of serum aminotransferases, fasting lipid profile and serum glucose, anthropometric parameters, and nutritional status at 0 and 12 months. A low calorie diet was prescribed for all patients. Serum alanine aminotransferase, high-density lipoprotein, insulin, and glucose concentrations and thehomeostasis model assessment-insulin resistance (HOMA-IR) index were reduced significantly at the end of study (P < 0.05). The BMI declined, but without statistical significance. Aspartate aminotransferase, gamma-glut...Continue Reading

References

Jul 11, 1998·Respiratory Medicine·A Gillissen, D Nowak
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S H CaldwellC J Driscoll
Oct 13, 2000·European Journal of Clinical Investigation·S C De RosaL A Herzenberg
Jan 11, 2001·The American Journal of Gastroenterology·A UygunK Dagalp
Apr 12, 2001·Seminars in Liver Disease·S Chitturi, G C Farrell
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Sep 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J OngN Boparai
Sep 25, 2001·Lancet·G MarchesiniN Melchionda
Jan 24, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dominique PessayreBernard Fromenty
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takehiko UesugiRonald G Thurman
May 3, 2002·Journal of the American College of Cardiology·Jan Sochman
Jul 11, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Gérard AilhaudFlorence Massiera
Aug 23, 2002·The American Journal of Gastroenterology·Stephen H Caldwell, Elizabeth E Hespenheide
Sep 26, 2002·Nutrition Reviews·Kapil MehtaSohrab Mobarhan
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Brent A Neuschwander-Tetri, Stephen H Caldwell
Jun 18, 2003·The American Journal of Gastroenterology·Jeanne M ClarkAnna Mae Diehl
Dec 17, 2003·Journal of Gastroenterology and Hepatology·Omer Nuri PamukAykut Ferhat Celik
Dec 17, 2003·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·David A KoobyWilliam R Jarnagin
Jan 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·M den BoerJ A Romijn
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·A UygunK Dagalp
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorPatrick Colin
May 12, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Miwa KawanakaGotaro Yamada
Jul 1, 2004·Alimentary Pharmacology & Therapeutics·S NairR P Perrillo
Sep 9, 2004·Alimentary Pharmacology & Therapeutics·S A HarrisonP Hayashi
Mar 22, 2005·Journal of Hepatology·Seela Ramesh, Arun J Sanyal
Apr 22, 2005·The American Journal of Gastroenterology·Elisabetta BugianesiGiulio Marchesini
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Ayako SuzukiKeith Lindor

❮ Previous
Next ❯

Citations

Apr 6, 2013·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Jia XiaoGeorge L Tipoe
Dec 24, 2011·Experimental Diabetes Research·Angela MazzaAntonino Belfiore
Jul 19, 2011·Therapeutic Advances in Gastroenterology·Lisa B Van Wagner, Mary E Rinella
Dec 12, 2012·Hepatitis Research and Treatment·Said A Al-BusafiMarc Deschenes
Nov 7, 2012·Journal of Pharmacology & Pharmacotherapeutics·Najah R HadiAsma Swadi
Sep 24, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Melissa A LindenR Scott Rector
May 7, 2014·World Journal of Hepatology·Zeynel Abidin Ozturk, Abdurrahman Kadayifci
Sep 12, 2017·Frontiers in Pharmacology·Bárbara González-FernándezMaría J Tuñón
May 1, 2019·Antioxidants·Špela ŠalamonIrina Milisav
Jul 4, 2015·World Journal of Hepatology·Aparna BhatMamatha Bhat

❮ Previous
Next ❯

Related Feeds

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Related Papers

International Journal of Food Sciences and Nutrition
Stergios A PolyzosAristidis Slavakis
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Masato YonedaAtsushi Nakajima
© 2021 Meta ULC. All rights reserved