Combination of PDT photosensitizers with NO photodononors

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Aurore Fraix, Salvatore Sortino

Abstract

Combination of photodynamic therapy (PDT) with other treatment modalities is emerging as one of the most suitable strategies to increase the effectiveness of therapeutic action on cancer and bacterial diseases and to minimize side effects. This approach aims at exploiting the additive/synergistic effects arising from multiple therapeutic species acting on different mechanistic pathways. The coupling of PDT with photocontrolled release of nitric oxide (NO) through the appropriate assembly of PDT photosensitizers (PSs) and NO photodonors (NOPDs) may open up intriguing avenues towards new and still underexplored multimodal therapies not based on "conventional" drugs but entirely controlled by light stimuli. In this contribution, we present an overview of the most recent advances in this field, illustrating several strategies to assemble PSs and NOPDs allowing them to operate independently without reciprocal interferences and describing the potential applications with particular emphasis on their impact in anticancer and antibacterial research.

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Citations

Mar 12, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Aurore FraixSalvatore Sortino
Jun 5, 2019·Nanomaterials·André Luiz TessaroSalvatore Sortino
May 11, 2019·Chemistry : a European Journal·Cristina ParisiSalvatore Sortino
Jul 10, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Antonio C RovedaDaniel R Cardoso
Aug 7, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Aurore FraixSalvatore Sortino
May 22, 2020·Chemical Communications : Chem Comm·Aurore FraixSalvatore Sortino
Aug 29, 2020·Biomaterials Science·Susan OliverCyrille Boyer
Sep 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mimimorena SeggioSalvatore Sortino
May 27, 2020·Chemistry : a European Journal·Cristina ParisiSalvatore Sortino
Nov 11, 2019·Antioxidants·Loretta LazzaratoSalvatore Sortino
Aug 14, 2019·Frontiers in Chemistry·Jian ChengJinming Hu
Sep 20, 2019·Antioxidants·Emily Hays, Benjamin Bonavida
Aug 3, 2019·International Journal of Molecular Sciences·Mimimorena SeggioSalvatore Sortino
Apr 19, 2020·Cell Biochemistry and Biophysics·Albert W Girotti, Witold Korytowski
Mar 7, 2021·Journal of Photochemistry and Photobiology. B, Biology·Clara M G de FariaVanderlei S Bagnato
Apr 15, 2020·Molecular Pharmaceutics·Aurore FraixSalvatore Sortino
Oct 31, 2020·Chemical Reviews·Roy WeinstainPetr Klán
Nov 5, 2021·Chemical Communications : Chem Comm·William Rodríguez-CórdobaJorge Peon

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Methods Mentioned

BETA
fluorescence imaging
Transmission microscopy
fluorescence microscopy
irradiating
confocal microscopy

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