Combination of photodynamic therapy + immunotherapy + chemotherapy in murine leukiemia

Neoplasma
G CantiA Nicolin

Abstract

Photodynamic therapy (PDT) is a treatment for cancer based on the photosensitization of tumor cells by photosensitive drugs and their subsequent destruction on exposure to light of particular wavelength. The combination of drug uptake in malignant tissues and selective delivery of laser-generated light provides an effective therapy with efficient tumor citotoxicity and minimal normal tissue damage. Since immune response of the host is important in the control of tumor growth and spreading, PDT is able to increase the antitumor immunity. In our laboratory we examined the antitumor effect of combination of PDT, with photoactivated M-THPC (meta-tetrahydroxyphenylchlorin, FOSCAN, Temoporphirin), adoptive immunotherapy, with immune lymphocytes, and chemotherapy on advanced murine tumors. Mice bearing L1210 tumor were treated at day +4 with Navelbine (NVB 1mg/Kg), at day +5,+6 with PDT (0.3mg/Kg of mTHPC and 100mW/cm(2) x 200'' of exposure of laser light), and at day + 7 with immune lymphocytes(IL), collected from mice pretreated with PDT(2x10(7) cells). The results show that the combination NVB + PDT + IL demonstrates a significant synergistic antitumor effect while the chemotherapy treatment with low dose of the drug is uneffective...Continue Reading

Citations

Aug 19, 2011·Photochemistry and Photobiology·Mathias O Senge, Johan C Brandt
Aug 14, 2012·Expert Review of Clinical Immunology·Ying-Ying HuangMichael R Hamblin
Feb 26, 2011·Expert Review of Respiratory Medicine·Joseph S Friedberg
Mar 19, 2013·Journal of Healthcare Engineering·Toshihiro KushibikiMiya Ishihara
Nov 8, 2014·Technology in Cancer Research & Treatment·N Patrik BrodinWolfgang A Tomé
Sep 6, 2017·Free Radical Research·Rahul BhattacharyyaSubrata Chattopadhyay
Jan 8, 2021·Frontiers in Chemistry·Neelam ThakurParames C Sil

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