Combination of Salvia miltiorrhiza and ligustrazine attenuates bleomycin-induced pulmonary fibrosis in rats via modulating TNF-α and TGF-β

Chinese Medicine
Cheng-Liang HuangXian-Ming Fan

Abstract

Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressive therapies such as dexamethasone (DEX) are often associated with side effects. Recently, combination of two Chinese herbal medicine preparations, Salvia miltiorrhiza and ligustrazine (SML), serves as an alternative medicine for treatment of IPF in clinical practices in China. The aim of this study is to compare the anti-fibrotic effect of SML with that of DEX and to investigate the underlying mechanisms. A rat model of bleomycin (BLM) induced pulmonary fibrosis was used in this study. Ninety rats were assigned to six groups: control group; BLM-group; BLM and dexamethasone group (BLM + DEX); BLM + low-dose SML; BLM + medium-dose SML and BLM + high-dose SML. Rats were sacrificed on day 7, 14 and 28 after treatment. The extent of alveolitis and fibrosis was observed by H&E and Masson's trichrome staining. The expressions of TNF-α, TGF-β1 and SMAD4 were determined and quantified by immunohistochemical analysis. The serum levels of TNF-α and TGF-β1 were further quantified by ELISA kits. Both DEX and SML treatment attenuated B...Continue Reading

References

Oct 19, 2010·Therapeutic Advances in Respiratory Disease·William R CowardGisli Jenkins
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Oct 27, 2012·The European Respiratory Journal·Wim A WuytsGeert M Verleden
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Mar 16, 2016·Pulmonary Medicine·Nergiz H TurgutEmre Arslanbas

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Citations

Sep 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shanjun YangQiang Tang
Dec 7, 2018·Journal of Cellular Biochemistry·Huimei WangMingwei Zhang
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yukun ZhangZhidong Liu

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Methods Mentioned

BETA
light microscopy
ELISA

Software Mentioned

Graphic context
Leica
ImagePro
ImagePro plus
Graphpad Prism

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