Abstract
To identify the potential influence of antimuscarinics on morphometric parameters of the prostate in patients with benign prostatic enlargement and overactive bladder. Non-neurological patients with prostate volume >30 mL, predominately storage lower urinary tract symptoms, three or more urgency episodes per 24 h, maximum flow rate ≥10 mL/s and post-void residual ≤100 mL were recruited for this study. They were randomized to receive either tamsulosin or tamsulosin + solifenacin. Patients were submitted to transrectal and transvesical ultrasonography, pressure-flow study and prostate-specific antigen test, and completed the International Prostate Symptom Score, bladder diary and overactive bladder questionnaire at induction and at 6 months. End-study changes in morphometric prostate parameters (total prostate and adenoma volumes, prostate vascularity), as measured by transrectal ultrasound, were the principal outcomes. A reduction in total prostate volume (mean -9.5%) was noted in the combination group, as opposed to an increase in the monotherapy group (+9.2%; P < 0.001). Similar changes were reflected in adenoma volume (monotherapy +17.4% vs combination -12.5%, P = 0.001) and in prostate vascularity (monotherapy +149.3% vs com...Continue Reading
References
Feb 15, 1997·The Prostate·W RayfordG V Shah
Aug 10, 2000·Urological Research·K ObaraK Takahashi
Sep 26, 2000·Neurourology and Urodynamics·R M LevinJ A Gosling
Apr 12, 2002·Neurourology and Urodynamics·Werner SchäferUNKNOWN International Continence Society
Aug 23, 2002·Pharmacology & Therapeutics·S VenturaFrederick Mitchelson
May 29, 2003·The Journal of Urology·A AthanasopoulosG Barbalias
May 29, 2003·British Journal of Cancer·J V PartinN Kyprianou
Aug 9, 2003·International Journal of Impotence Research·E RicciM Lavezzari
Mar 3, 2004·The Prostate·Anastasios Tahmatzopoulos, Natasha Kyprianou
Oct 13, 2004·BJU International·Ji Youl LeeMichael B Chancellor
Nov 11, 2005·The Journal of Urology·Steven A KaplanAlexis E Te
Mar 2, 2006·BJU International·Kevin McVary
Jun 6, 2006·British Journal of Pharmacology·Paul AbramsAlan J Wein
Sep 8, 2006·BJU International·Yao-Chi ChuangMichael B Chancellor
Nov 7, 2006·The Journal of Urology·Yao-Chi Chuang, Michael B Chancellor
Nov 16, 2006·JAMA : the Journal of the American Medical Association·Steven A KaplanZhonghong Guan
Jan 5, 2007·Biological & Pharmaceutical Bulletin·Akiyoshi OhtakeKeiji Miyata
Nov 17, 2007·BJU International·Germar-M PinggeraHannes Strasser
Dec 28, 2007·European Urology·Lambertus P W WitteMartin C Michel
Apr 22, 2008·The Journal of Urology·Hsin-Tzu Liu, Hann-Chorng Kuo
Jul 25, 2008·European Urology·João SilvaFrancisco Cruz
Jan 31, 2009·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·Dionisios MitropoulosPanagiotis Karayannacos
Aug 18, 2009·BMC Urology·João SilvaPaulo Dinis
Oct 15, 2009·European Urology·Claus G RoehrbornUNKNOWN CombAT Study Group
Jan 11, 2014·Investigative Ophthalmology & Visual Science·Adrian GerickeNorbert Pfeiffer
Citations
Oct 24, 2019·Lower Urinary Tract Symptoms·Osamu SomaChikara Ohyama
Feb 11, 2021·The Cochrane Database of Systematic Reviews·Ran PangJae Hung Jung
Apr 1, 2021·World Journal of Urology·Marcelo Langer WroclawskiJeremy Yuen-Chun Teoh