PMID: 9442783Jan 27, 1998Paper

Combination of systemic acetazolamide and topical dorzolamide in reducing intraocular pressure and aqueous humor formation

Ophthalmology
L F RosenbergJ M Ruderman

Abstract

The study aimed to determine whether topical dorzolamide and systemic acetazolamide have an additive effect on intraocular pressure (IOP) and aqueous humor formation (AHF). This was a prospective, open-label, two-protocol clinical study. Sixteen patients with ocular hypertension or with primary open-angle glaucoma were studied. Baseline AHF was measured by computerized fluorophotometry and IOP by pneumatonometry without antiglaucoma therapy. In the first protocol, dorzolamide was randomized to one eye (N = 10) and IOP and AHF measurements were repeated. One week later, having used dorzolamide in one eye three times daily, patients had measurements performed before and after the single administration of oral acetazolamide 250 mg. In the second protocol, having used acetazolamide 250 mg four times daily for 4 to 7 days (N = 6), patients had measurements performed before and after a single drop of dorzolamide was instilled randomly into one eye. The patient continued acetazolamide and unilateral dorzolamide for 4 to 7 more days and returned for IOP and AHF measurements. Intraocular pressure and AHF were measured in treated and contralateral control eyes. In the first protocol, IOP (mmHg +/- standard deviation) was significantly (P...Continue Reading

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Citations

Sep 24, 2004·The Journal of Membrane Biology·C W Do, M M Civan
Jul 11, 2003·Survey of Ophthalmology·Louis Cantor
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Aug 27, 2021·The British Journal of Ophthalmology·Ari StonerBrent Siesky

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