Abstract
Prostate cancer (PCa) is a common tumor disease in western countries and a leading cause of cancer-driven mortality in men. Current methods for prostate cancer detection, like prostate-specific antigen screening, lead to significant overtreatment. The purpose of the study was to analyze circulating microRNAs in serum as non-invasive biomarkers in patients with diagnosis of prostate cancer and healthy individuals. This preliminary study included a population of 20 patients with mean age of 68.6 years and mean PSA of 21.3 ng/ml. Eight healthy patients were used as control. MiRNAs were quantified in the total RNA fraction extracted from serum and levels of five microRNAs (miR-106b, miR-141, miR-21, mir-34a, and miR-375) were quantified by RT-qPCR. Statistical analyses evaluated correlation between clinicopathological data and miRNAs expression levels. Relative expression ratios of miR-106b, miR-141-3p, miR-21, and miR-375 were significantly increased (1.8-, 1.9-, 2.4-, and 2.6-fold, respectively) in the PCa group compared to healthy control. Using receiver operating characteristics, the highest area under the curve equal to 0.906 was obtained for miR-357 and indicates a very good diagnostic properties of this biomarker. We found ...Continue Reading
References
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 10, 2007·Cancer Research·Kati P PorkkaTapio Visakorpi
Sep 25, 2007·Oncogene·M OzenM Ittmann
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Aug 5, 2008·Cancer Research·Stefan AmbsCarlo M Croce
Sep 1, 2009·Trends in Molecular Medicine·Paolo GandelliniNadia Zaffaroni
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Jan C BraseHolger Sültmann
Jan 29, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fulya Yaman AgaogluUgur Gezer
Jul 5, 2011·Clinical Genitourinary Cancer·Jason C GonzalesDavid C Ward
Sep 13, 2011·PloS One·Michaela B KirschnerGlen Reid
Mar 24, 2012·Journal of Translational Medicine·Martina RedovaOndrej Slaby
May 2, 2012·BMC Bioinformatics·Chengxi YeDouglas W Yu
May 2, 2013·British Journal of Cancer·A Sita-LumsdenC L Bevan
Mar 26, 2014·Actas urologicas españolas·V Medina-VillaamilF Gómez-Veiga
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Dec 19, 2014·DNA and Cell Biology·Darina KachakovaRadka Kaneva
Mar 20, 2015·Drug Delivery and Translational Research·Christa HaldrupKarina D Sorensen
Apr 18, 2015·BMC Cancer·Silvia AntolínManuel Valladares-Ayerbes
Jul 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaoying ZhouGuoxin Zhang
Jul 23, 2015·Theranostics·Gloria BertoliIsabella Castiglioni
Aug 5, 2015·Journal of Clinical Medicine·Brian D KellyMichael J Kerin
Jan 12, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Xavier Filella, Laura Foj
Jun 9, 2016·Neoplasma·Y GaoS Li
Oct 30, 2016·International Journal of Molecular Sciences·Xavier Filella, Laura Foj
Mar 23, 2017·BMC Urology·Hung N LuuGiuliano Di Pietro
Aug 22, 2017·Cancer Letters·Rajnee KanwalSanjay Gupta
Sep 15, 2017·PloS One·Marilesia Ferreira de SouzaIlce Mara de Syllos Cólus
Feb 1, 2018·The Prostate·Alicia C McDonaldEmanuela Taioli
Jun 6, 2018·Cancer Biomarkers : Section a of Disease Markers·Yanying ZhaoKongxi Zhu
Citations
Nov 7, 2019·The Journal of Gene Medicine·Guozhu LiuHao Zhang
Oct 3, 2019·Expert Review of Molecular Diagnostics·Emmy BoerrigterJack A Schalken
Feb 28, 2020·Medicina·Vlad Cristian MunteanuIoan Coman
Apr 9, 2020·Epigenomics·Irena AbramovicNino Sincic
Jun 3, 2020·Medicine·Yun YeSu-Liang Li
Apr 10, 2019·Expert Review of Molecular Diagnostics·Vera ConstâncioRui Henrique
May 14, 2020·Clinical and Experimental Medicine·Ilgiz GareevShiguang Zhao
Sep 15, 2020·Journal of Extracellular Vesicles·Marta CollettiAngela Di Giannatale
Jan 31, 2019·Diagnostics·Jochen Neuhaus, Bo Yang
Oct 17, 2019·Journal of Clinical Medicine·Michela BottaniGiovanni Lombardi
May 27, 2020·Journal of Immunology Research·Wei JinYan Song
Apr 16, 2020·Molecular Cancer·Maureen LabbéDelphine Fradin
Mar 19, 2019·Oncology Letters·Weiyun WuJuanhua Quan
Apr 5, 2019·International Neurourology Journal·Won Tae KimWun-Jae Kim
Aug 30, 2019·Biomarkers in Medicine·Lynn Sorbara, Sudhir Srivastava
Dec 19, 2019·Frontiers in Oncology·Adil MalikJyotsna Batra
Aug 14, 2020·International Journal of Molecular Sciences·Ewa CiszkowiczMirosław Tyrka
Nov 25, 2020·Journal of Nanobiotechnology·Manfred KunzAchim Aigner
Jan 25, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yudong WuDongming Xing
Jan 9, 2021·Journal of Translational Medicine·Martyna ParolDariusz Grzanka
Mar 14, 2021·Biomarker Research·Ana E Jenike, Marc K Halushka
Mar 20, 2021·Therapeutic Advances in Urology·Anna SaltmanAbhinav Sidana
Aug 4, 2020·Asian Journal of Urology·Ieva EringyteClaire E Fletcher
Mar 22, 2021·Life Sciences·Yang LiuChaolai Man
Apr 4, 2021·Pharmaceutics·Noemi Arrighetti, Giovanni Luca Beretta
Apr 4, 2021·Biomolecules·Bodo C Melnik
Jun 1, 2021·PeerJ·Shiyu ZhangWei Zhu
Jun 3, 2021·Sensors·Wai-Hung LeungWen-Hui Weng
Jun 12, 2021·Nature Communications·Shenglin CaiJoshua B Edel
Sep 13, 2020·Pathology, Research and Practice·Cunjin NanYinghe Chen
Jun 27, 2021·Pharmacology & Therapeutics·Maria Adamaki, Vassilios Zoumpourlis
Jul 3, 2021·Cancers·Cora Palanca-BallesterAlfonso Calvo
Jul 8, 2021·Endocrinology·Megan LudwigJustin M Drake
Sep 8, 2021·Frontiers in Oncology·Xiaoyun HuHuizhe Wu