Combination of tumour markers CEA and CA19-9 improves the prognostic prediction in patients with pancreatic cancer

Journal of Clinical Pathology
Daniel ReitzMartin Pichler

Abstract

Tumour markers including carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA19-9) are frequently determined at the time of diagnosis in patients with pancreatic cancer. Several studies indicate a prognostic relevance of these markers in pancreatic cancer, but space for improvement with regard to the predictive accuracy and ability is given. In this work, the main focus is on mathematical combinations of these two tumour markers in order to validate an improvement of prognostic test results in terms of sensitivity and specificity. This retrospective study includes 393 patients with pancreatic cancer, who were treated between the years 2005 and 2012 at the Division of Oncology, Medical University of Graz, Austria. The goal of this study was to explore whether an appropriate combination of two tumour markers leads to a statistically significant improvement of the prognostic prediction. Receiver operating characteristic curves comparison analyses with the classification variable cancer-specific survival showed that the mathematical product of two tumour markers (TM(product)= (CEA×CA19-9); area under the curve (AUC)=0.727; 95% CI 0.680 to 0.770) is significantly better than CEA alone (AUC=0.644; 95% CI 0.594 to 0.691; p=...Continue Reading

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Citations

May 23, 2015·Drug Discoveries & Therapeutics·Yoshinori InagakiNorihiro Kokudo
Nov 12, 2015·Thoracic Cancer·Hongwei GuoJian Zhang
Mar 25, 2017·International Journal of Molecular Sciences·John C Chang, Madappa Kundranda
Mar 5, 2016·World Journal of Gastroenterology : WJG·Simone PolvaniAndrea Galli
Feb 6, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Labrinus van ManenJ Sven D Mieog
Mar 8, 2017·Annals of Surgery·Guopei LuoXianjun Yu
Jul 31, 2019·Journal of Clinical Medicine·Hsu WuSung-Hsin Kuo
Nov 10, 2020·Asia-Pacific Journal of Clinical Oncology·Yang YuHao Chen
Jan 7, 2019·Seminars in Oncology·Si Shi, Xianjun Yu
Jul 29, 2017·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Zhijian WenBaohua Zhang

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