Combination of Urinary Biomarkers Improves Early Detection of Acute Kidney Injury in Patients With Heart Failure

Circulation Journal : Official Journal of the Japanese Circulation Society
Chia-Hung YangYung-Chang Chen

Abstract

Acute kidney injury (AKI) is associated with morality and repeated hospitalization, and is frequently encountered in patients with acute decompensated heart failure (ADHF). However, few effective tools exist for early AKI identification and risk stratification. This was a prospective observational study conducted in the coronary care unit (CCU) of a tertiary care university hospital. Patients with a diagnosis of ADHF and who were using diuretics were enrolled.Samples collected between December 2013 and February 2015 were tested for serum cystatin C (Cys-C), urinary neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 (KIM-1). Demographic, clinical, and laboratory data were evaluated. A total of 103 adult patients with a mean age of 68 years were investigated. AKI was diagnosed in 49 patients (47.6%). For predicting intrinsic AKI on the first day of CCU admission, a combination of Cys-C and urine KIM-1 yielded an excellent area under the receiver operating characteristic curve of 0.828, a sensitivity of 71.0%, and specificity of 43.0%, for an overall accuracy of 78%. In this study, we found that combinations of the biomarker (Cys-C and KIM-1) were an effective clinical model for predicting AKI in patients wit...Continue Reading

References

Aug 26, 2004·Kidney International·Stefan Herget-RosenthalAndreas Kribben
Sep 24, 2005·Journal of the American Society of Nephrology : JASN·Glenn M ChertowDavid W Bates
Aug 25, 2006·Journal of the American Society of Nephrology : JASN·Steven D WeisbordPaul M Palevsky
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Tomas Berl, William Henrich
Oct 17, 2007·Annual Review of Pharmacology and Toxicology·Vishal S VaidyaJoseph V Bonventre
Nov 15, 2008·Journal of the American College of Cardiology·Claudio RoncoRinaldo Bellomo
Mar 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Joseph V Bonventre
Aug 28, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Jay L KoynerPatrick T Murray
Oct 12, 2010·Current Opinion in Critical Care·Joseph V Bonventre, Li Yang
Dec 1, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Margarida AlvelosPaulo Bettencourt
Jan 18, 2011·Nature Medicine·Neal ParagasJonathan Barasch
Jul 16, 2011·International Journal of Nephrology·Massimo de CalClaudio Ronco
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Sep 19, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Ming-Jer HsiehChun-Chieh Wang
Dec 5, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihiro ShirakabeKyoichi Mizuno
Mar 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul M PalevskySteven D Weisbord
Jun 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JSN, JRS and JCS Joint Working Group
Oct 11, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Daisuke AbeKazutaka Aonuma
Jun 4, 2014·The Journal of Clinical Investigation·Bruce A Molitoris
Dec 3, 2014·The Annals of Thoracic Surgery·Chih-Hsiang ChangYung-Chang Chen

❮ Previous
Next ❯

Citations

Mar 8, 2018·Heart Failure Reviews·Michele CorrealeUNKNOWN Master Program Students on Drug Development for Heart Failure
Jul 11, 2018·Current Heart Failure Reports·Agata Bielecka-DabrowaStephan von Haehling
May 17, 2019·Terapevticheskiĭ arkhiv·S N NasonovaS N Tereshchenko
Mar 8, 2017·Critical Care : the Official Journal of the Critical Care Forum·Yujun DengChunbo Chen
Apr 28, 2018·Critical Care : the Official Journal of the Critical Care Forum·Jian-Jhong WangKwan-Dun Wu
Feb 14, 2017·Journal of Translational Internal Medicine·Zhi-Yong Peng
Oct 10, 2018·Nephrology·Pei-Chun FanYung-Chang Chen
Dec 8, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Min HurJae-Hyon Bahk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.