Combination of Vaccine-Strain Measles and Mumps Viruses Enhances Oncolytic Activity against Human Solid Malignancies

Cancer Investigation
Ho Anh SonNguyen Linh Toan

Abstract

Oncolytic measles and mumps viruses (MeV, MuV) have a potential for anti-cancer treatment. We examined the anti-tumor activity of MeV, MuV, and MeV-MuV combination (MM) against human solid malignancies (HSM). MeV, MuV, and MM targeted and significantly killed various cancer cell lines of HSM but not normal cells. MM demonstrated a greater anti-tumor effect and prolonged survival in a human prostate cancer xenograft tumor model compared to MeV and MuV. MeV, MuV, and MM significantly induced the expression of immunogenic cell death markers and enhanced spleen-infiltrating immune cells. In conclusion, MM combination significantly improves the treatment of human solid malignancies.

References

Jan 1, 1980·Scandinavian Journal of Immunology·B HärfastP Perlmann
Feb 7, 2001·Journal of Virology·C Servet-DelpratC Rabourdin-Combe
May 14, 2003·Journal of Virology·Christina M UlaneCurt M Horvath
Nov 1, 1950·A.M.A. Archives of Dermatology and Syphilology·G T PACK
Oct 9, 2004·Cancer Gene Therapy·Bart Everts, Henk G van der Poel
Mar 16, 2005·Journal of Virology·Toru KubotaAtsushi Kato
May 23, 2006·Drug Discovery Today·Brahm H SegalJohn R Subjeck
May 27, 2006·Experimental Hematology·Hooi Tin OngKah-Whye Peng
Feb 11, 2009·Current Topics in Microbiology and Immunology·S J Russell, K W Peng
Dec 24, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kathryn Ottolino-PerryJ Andrea McCart
Nov 23, 2010·Expert Review of Vaccines·Patrycja J Lech, Stephen J Russell
Dec 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu ZhangAdele K Fielding
Feb 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eleni M KarapanagiotouKevin J Harrington
May 18, 2013·Cell Death & Disease·O KryskoD V Krysko
Jan 3, 2015·Food & Function·J E NortonI T Norton
Apr 29, 2015·Gut and Liver·UNKNOWN Korean Liver Cancer Study Group (KLCSG), UNKNOWN National Cancer Center, Korea (NCC)
Dec 8, 2015·Molecular Therapy Oncolytics·Olga V MatveevaPeter M Chumakov
Dec 8, 2015·Molecular Therapy Oncolytics·Olga V MatveevaPeter M Chumakov
Jan 15, 2016·European Journal of Immunology·Darren Qiancheng TanNaoki Yamamoto
Jan 1, 2015·Molecular Therapy Oncolytics·Dana Haddad, Yuman Fong
Apr 28, 2016·Molecular Therapy Oncolytics·Koichiro ShojiChieko Kai
Aug 25, 2016·Molecular Therapy Oncolytics·Arun AmmayappanMark J Federspiel

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Citations

Jul 24, 2020·International Journal of Molecular Sciences·Kenneth Lundstrom
Feb 5, 2021·Cancers·Christine E Engeland, Guy Ungerechts
Mar 12, 2021·Current Oncology·Vanessa InnaoAlessandro Allegra
May 14, 2021·Virology Journal·Amir Sasan Mozaffari NejadAmir Ghaemi
Jun 1, 2021·Frontiers in Oncology·Liese VandeborneGauthier Bouche

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