Combination of Vancomycin or Daptomycin and Beta-lactam Antibiotics: A Meta-analysis.

Pharmacotherapy
Pramodini B Kale-PradhanMichael J Rybak

Abstract

Observational and randomized controlled trials of the combination of vancomycin or daptomycin with a beta-lactam (BL) in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia have shown conflicting results on patient outcomes. The primary purpose of this meta-analysis was to compare clinical failure with the combination of vancomycin or daptomycin with a BL versus vancomycin or daptomycin monotherapy in MRSA bacteremia or endocarditis. A systematic literature search of PubMed, Embase, CINAHL, and meeting proceedings was conducted from inception through February 11, 2020, to identify relevant studies. The primary outcome was clinical failure and secondary outcomes were mortality, nephrotoxicity, and bacteremia. The meta-analysis was performed using Comprehensive Meta Analysis (version 3.0) with a random effects model. Outcomes were reported as odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Nine studies of 1636 patients receiving vancomycin or daptomycin monotherapy versus the combination of vancomycin or daptomycin plus BL for MRSA bacteremia were included. Results showed combination therapy was associated with significantly lower clinical failure rates (OR 0.56, 95% CI 0.39-0.79, I2  ...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jun 15, 2010·Diagnostic Microbiology and Infectious Disease·Elizabeth A NeunerPeggy S McKinnon
Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine LiuHenry F Chambers
Jun 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Abhay DhandGeorge Sakoulas
Jun 20, 2012·Emerging Infectious Diseases·Mina PastagiaStephen G Jenkins
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Thomas J DilworthRenée-Claude Mercier
Nov 26, 2013·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jessica K OrtwineMichael J Rybak
Feb 3, 2015·Seminars in Respiratory and Critical Care Medicine·J S DavisS Y C Tong
Sep 10, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joshua S DavisUNKNOWN Australasian Society for Infectious Diseases Clinical Research Network
Jan 20, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Andrew E SimorUNKNOWN Canadian Nosocomial Infection Surveillance Program
Nov 30, 2016·Antimicrobial Agents and Chemotherapy·W Cliff RutterDavid S Burgess
May 29, 2018·Diagnostic Microbiology and Infectious Disease·Nivedita B SinghMichael J Rybak
Apr 1, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S WeisM W Pletz
Feb 12, 2020·JAMA : the Journal of the American Medical Association·Steven Y C TongUNKNOWN Australasian Society for Infectious Diseases Clinical Research Network

❮ Previous
Next ❯

Citations

Oct 8, 2021·The Journal of Antimicrobial Chemotherapy·Carla C C R de CarvalhoAdriana E Rosato
May 17, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Warren RoseGeorge Sakoulas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.