Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity

Advanced Pharmaceutical Bulletin
Goltaj BayramiReza Badalzadeh

Abstract

Purpose: Diabetic hearts are resistant to cardioprotection by ischemic-postconditioning (IPostC). Protection of diabetic hearts and finding related interfering mechanisms would have clinical benefits. This study investigated the combination effects of vildagliptin (Vilda) and IPostC on cardioprotection and the levels of autophagy and mitochondrial function following myocardial ischemia/reperfusion (I/R) injury in type-II diabetic rats. Methods: Diabetes was established by high fat diet/low dose of streptozotocin and lasted for 12 weeks. The diabetic rats received Vilda (6 mg/kg/day, orally) for one month before I/R. Myocardial regional ischemia was induced through the ligation of left coronary artery, and IPostC was applied immediately at the onset of reperfusion. The infarct size was assessed by a computerised planimetry and left ventricles samples were harvested for cardiac mitochondrial function studies (ROS production, membrane potential and staining) and western blotting was used for determination of autophagy markers. Results: None of Vilda or IPostC but combination of them could significantly reduce the infarct size of diabetic hearts, comparing to control (P<0.001). IPostC could not significantly affect p62 express...Continue Reading

References

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Sep 14, 2017·Journal of Cardiovascular Pharmacology and Therapeutics·Goltaj BayramiReza Badalzadeh

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Citations

Feb 28, 2020·Renal Failure·Iman O SherifNora H Al-Shaalan
May 23, 2020·Nature Communications·Qinglei YinGuang Ning
Nov 9, 2018·Oxidative Medicine and Cellular Longevity·Iman O Sherif, Nora H Al-Shaalan
Jan 4, 2021·International Immunopharmacology·Iman O Sherif, Nora H Al-Shaalan

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Methods Mentioned

BETA
ELISA
X-ray

Software Mentioned

ImageJ
SPSS
IPostC
Image J

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