Combination of Zinc and All-Trans Retinoic Acid Promotes Protection against Listeria monocytogenes Infection

PloS One
Yussaira CastilloMasahisa Watarai

Abstract

Zinc (Zn) is the second most abundant transition metal after iron. It plays a vital role in living organisms and affects multiple aspects of the immune system. All-trans retinoic acid (atRA) is an isomeric form of the vitamin A or retinol. It possesses the greatest biological activity of Vitamin A. Vitamin A and related retinoids influence many aspects of immunity. In this study, we demonstrated that treatment with a combination of Zn and atRA contributes to host resistance against infection by Listeria monocytogenes. Pretreatment with Zn and atRA enhanced resistance against L. monocytogenes infection in mice and treatment with both Zn and atRA showed a higher protective effect than treatment with either alone. Supplementation with Zn, atRA or their combination decreased the number of L. monocytogenes present in target organs. In vitro, supplementation increased the bacterial uptake by macrophage cells and reduced the replication of L. monocytogenes. Our results suggest that the combination of Zn and atRA has a great bacteriostatic impact on L. monocytogenes and its infection.

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Citations

Sep 27, 2016·PloS One·Yussaira CastilloMasahisa Watarai
Feb 9, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Samia BouamamaSid Ahmed Merzouk
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Benoît FolignéCatherine Daniel
Jan 10, 2019·Journal of Immunology Research·Hong GaoFudi Wang
Feb 27, 2021·Ecotoxicology and Environmental Safety·Jinjin JingPeng Xue
Jul 22, 2018·Microbiology Spectrum·Laura Luque-SastreSéamus Fanning

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA
light microscopy
ELISAs

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