Combination Therapies: Quantifying the Effects of Transarterial Embolization on Microwave Ablation Zones

Journal of Vascular and Interventional Radiology : JVIR
Erica M KnavelPaul F Laeseke

Abstract

To quantify the effect of transarterial embolization on microwave (MW) ablations in an in vivo porcine liver model. Hepatic arteriography and cone-beam computed tomography (CT) scans were performed in 6 female domestic swine. Two lobes were embolized to an endpoint of substasis with 100-300-μm microspheres. MW ablations (65 W, 5 min) were created in embolized (n = 15) and nonembolized (n = 12) liver by using a 2.45-GHz system and single antenna. Cone-beam CT scans were obtained to monitor the ablations, document gas formation, and characterize arterial flow. Ablation zones were excised and sectioned. A mixed-effects model was used to compare ablation zone diameter, length, area, and circularity. Combined transarterial embolization and MW ablation zones had significantly greater area (mean ± standard deviation, 11.8 cm2 ± 2.5), length (4.8 cm ± 0.5), and diameter (3.1 cm ± 0.6) compared with MW only (7.1 cm2 ± 1.9, 3.7 cm ± 0.6, and 2.4 cm ± 0.3, respectively; P = .0085, P = .0077, and P = .0267, respectively). Ablation zone circularity was similar between groups (P = .9291). The larger size of the combined ablation zones was predominantly the result of an increase in size of the peripheral noncharred zone of coagulation (1.3 cm...Continue Reading

Citations

Sep 7, 2019·Therapeutic Advances in Gastroenterology·Tian-Qi ZhangJin-Hua Huang
Dec 22, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Eliodoro FaiellaRosario Francesco Grasso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.