Combination therapy: A feasibility strategy for CAR-T cell therapy in the treatment of solid tumors

Oncology Letters
Jinjing XuLongzhou Chen

Abstract

Chimeric antigen receptor (CAR) T-cell therapies have been demonstrated to have durable and potentially curative therapeutic efficacies in patients with hematological malignancies. Currently, multiple clinical trials in CAR-T cell therapy have been evaluated for the treatment of patients with solid malignancies, but have had less marked therapeutic effects when the agents are used as monotherapies. When summarizing relevant studies, the present study found that combination therapy strategies for solid tumors based on CAR-T cell therapies might be more effective. This review will focus on various aspects of treating solid tumors with CAR-T cell therapy: i) The therapeutic efficacy of CAR-T cell monotherapy, ii) the feasibility of the CAR-T cell therapy in conjunction with chemotherapy, iii) the feasibility of CAR-T cell therapy with radiotherapy, iv) the feasibility of CAR-T cell therapy with chemoradiotherapy, and v) the feasibility of the combination of CAR-T cell therapy with other strategies.

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Citations

Jul 4, 2020·Journal of Leukocyte Biology·Emmanuel DonnadieuVinicius Cotta-de-Almeida
Jul 12, 2019·Frontiers in Immunology·Dario DidonaMichael Hertl
Apr 16, 2021·Frontiers in Immunology·Zilong GuoPing Lei
Jun 12, 2021·Frontiers in Neuroscience·Luke MaggsSoldano Ferrone

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xenograft

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NCT02664363

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