PMID: 4611585Dec 7, 1974

Combination therapy for myelomatosis

British Medical Journal
L Azam, I W Delamore


Twenty-eight patients with multiple myeloma have been treated with a quadruple chemotherapeutic regimen consisting of 1, 3 bis (2-chloroethyl)-1-nitrosourea (BCNU), cyclophosphamide, melphalan, and prednisolone. Nineteen new patients and nine who had escaped from previous single-agent therapy were included in the study. The results to date, on eight criteria of response, seem to be superior to those obtained from previous chemotherapeutic regimens. The study has been in progress for 18 months and only three patients have died. Only one who had not received previous therapy died, and she had complicating hyperparathyroidism, which almost certainly contributed to her death.


Feb 17, 1969·JAMA : the Journal of the American Medical Association·S L Rivers, M E Patno
May 10, 1973·The New England Journal of Medicine·V T DeVita, P S Schein
Aug 1, 1972·Cancer·R AlexanianH E Wilson
Apr 19, 1969·British Medical Journal·J S Malpas
Jun 2, 1969·JAMA : the Journal of the American Medical Association·R AlexanianH E Wilson


Dec 1, 1975·British Journal of Haematology·S V Jones, H McFarlane
Jan 1, 1978·Medical and Pediatric Oncology·R M Lennan, H R Taylor

Related Concepts

Bone Marrow Examination
Clinical Trials
Cyclophosphamide, (S)-Isomer
Antibody Fragments
Kidney Function Tests

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