Combination therapy for systemic sclerosis-associated pneumatosis intestinalis

BMJ Case Reports
Kanyada KoysombatTim Orchard

Abstract

We present a case of a patient with pneumatosis intestinalis and pneumoperitoneum secondary to gastrointestinal systemic sclerosis, who presented following recurrent accident and emergency attendances with abdominal pain. Pneumatosis intestinalis is a rare complication of systemic sclerosis; management approaches focus largely on exclusion of life-threatening surgical pathologies and subsequent symptom control. To date, there are still no established gold-standard treatment strategy and no large-scale trial data to support a specific management strategy. We describe a case of successful medical management with a combination of antimicrobial, elemental diet and high-flow inhalation oxygen therapy, with supporting evidence of CT image confirming resolution. This case therefore contributes to the literature, being the first to report both symptomatic and radiological improvement following combination therapy without the need for surgical intervention.

References

Jan 1, 1979·Scandinavian Journal of Gastroenterology·W van der Linden, R Marsell
Oct 1, 1987·Diseases of the Colon and Rectum·P JauhonenT Karttunen
Mar 15, 1980·British Medical Journal·B W Ellis
Jul 1, 1995·Gastrointestinal Endoscopy·R BansalJ M Scheiman
Dec 1, 1995·Scandinavian Journal of Gastroenterology·B T Johnston, R J McFarland
May 23, 2007·AJR. American Journal of Roentgenology·Lisa M HoWilliam M Thompson
Oct 16, 2007·Digestive Diseases and Sciences·Robyn DomsicKlaus Bielefeldt
Mar 22, 2012·Internal Medicine Journal·A Balbir-GurmanY Braun-Moscovici
Aug 16, 2013·World Journal of Gastroenterology : WJG·Li-Li WuQing-Sen Liu
Aug 29, 2013·Case Reports in Radiology·Puneet Devgun, Hal Hassan
May 7, 2014·Mayo Clinic Proceedings·Joseph D FeuersteinTyler M Berzin
Dec 23, 2014·International Journal of Surgery Case Reports·Mehdi TahiriDawn Anderson
Jul 7, 2016·Nature Reviews. Gastroenterology & Hepatology·Anton Emmanuel
Oct 13, 2017·Annals of Medicine and Surgery·Manon JenkinsJames Williamson
Feb 22, 2018·Digestive Diseases and Sciences·Lazaros I SakkasSpyros Potamianos

❮ Previous
Next ❯

Citations

Aug 15, 2019·Digestive Diseases and Sciences·M BrighiV Tonini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
K YonemitsuY Koshiishi
The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Yoshihiro OkudaShuji Isaji
European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
J A NaiditchA Chin
The Netherlands Journal of Medicine
J C van Leeuwen, J C Nossent
© 2022 Meta ULC. All rights reserved