PMID: 8595513Jan 1, 1995Paper

Combination therapy from a clinician's perspective

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
F D Goebel

Abstract

A number of important scientific questions have been answered in recent years concerning how HIV causes disease and whether combinations of antiretroviral agents might be more effective than monotherapies. However, a considerable number of questions remain unanswered regarding when to start treatment and what regimen to start with. It is also obvious that significant disparity exists between what is possible in therapeutic terms, in the clinic, and what has been demonstrated in in vitro studies and clinical trials. In translating what we have learned about combination therapy in clinical trials to application in a clinical setting, it is necessary to consider a number of important factors. First, the availability of antiretroviral agents as licensed products varies considerably between countries, as do the indications for these agents. Physicians in many countries are presently faced with prescribing therapeutic regimens that are already known to be suboptimal. With the speed of release of new data, there is growing disparity between our therapeutic knowledge and what is possible in the clinic. Patient compliance is also a very important consideration in the development of combination therapy, as patients may be expected to tak...Continue Reading

Citations

Sep 27, 2003·Clinical Therapeutics·Anke RichterSusan L Dennett
Apr 1, 1997·Journal of Clinical Epidemiology·J R Ickovics, A W Meisler
May 1, 1993·Antimicrobial Agents and Chemotherapy·S Kaul, K A Dandekar
Aug 7, 2002·Journal of Clinical Pharmacology·Christine FalcozWilliam T Prince
Jun 14, 2013·AIDS and Behavior·Rebekah K HerschJoy Spencer

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