Combination therapy in exudative age-related macular degeneration: visual outcomes following combined treatment with photodynamic therapy and intravitreal bevacizumab

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Michael J WanTom G Sheidow

Abstract

To measure visual outcomes following combined treatment with photodynamic therapy (PDT) and intravitreal bevacizumab for exudative age-related macular degeneration (AMD). Single-centre, retrospective cohort analysis. One hundred and seventy-four eyes in 174 patients, representing a consecutive series of all patients with at least 6 months' follow-up after combined treatment with PDT and bevacizumab for exudative AMD. Each patient was treated with PDT, followed by intravitreal injection of bevacizumab approximately 30 minutes later. The patients were then followed at 8-12-week intervals. The primary outcome of the study was the mean change in visual acuity (VA) from baseline. One hundred seventy-four eyes in 174 patients completed at least 6 months' follow-up, with a mean duration of 10 months. The mean number of treatments was 3.0 for bevacizumab and 1.4 for PDT. After stabilization, the mean treatment-free interval was 193 days, and 52% of the patients did not require postinduction retreatment. Mean VA improved from baseline at 2, 4, and 6 months of follow-up (p < 0.05). In the subgroup analysis, treatment-naïve patients had more favorable visual outcomes (p < 0.05). The combination of PDT and intravitreal bevacizumab is an ef...Continue Reading

References

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Sep 7, 2007·Korean Journal of Ophthalmology : KJO·Eun Jee Chung, Hyoung Jun Koh

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Citations

Nov 28, 2018·Journal of Ophthalmic & Vision Research·Mitra FarnoodianNader Sheibani
Mar 24, 2011·Current Opinion in Ophthalmology·Allen Chiang, Carl D Regillo
Mar 28, 2012·Current Opinion in Ophthalmology·David R LallyCarl D Regillo

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