Combination therapy of canine osteosarcoma with canine bone marrow stem cells, bone morphogenetic protein and carboplatin in an in vivo model

Veterinary and Comparative Oncology
R E G RiciD A Maria

Abstract

Osteosarcoma (OSA) is the most common malignant bone cancer in children and dogs. The therapeutic protocols adopted for dogs and humans are very similar, involving surgical options such as amputation. Besides surgical options, radiotherapy and chemotherapy also are adopted. However, hematologic, gastrointestinal and renal toxicity may occur because of chemotherapy treatments. Recent study clearly showed that mesenchymal stem cells (MSCs) combined with recombinant human bone morphogenetic protein (rhBMP-2) may be associated with decreases of the tumorigenic potential of canine OSA. The aim of this study was to analyse the efficacy of chemotherapy with carboplatin and rhBMP-2 with MSCs in a canine OSA in vivo model. Canine OSA cells were implanted in mice Balb-c/nude with MSCs, rhBMP-2 and carboplatin. Flow cytometry and PCR for markers involved in tumour suppression pathways were analysed. Results showed that the combination of MSCs and rhBMP-2 reduced tumour mass and infiltration of neoplastic cells in tissues more efficiently than carboplatin alone. Thus it was demonstrated that the use of rhBMP-2 and MSCs, in combination with conventional antineoplastic, may be an efficient treatment strategy.

References

Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·R G ChiriviR Giavazzi
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
May 18, 1999·International Journal of Cancer. Journal International Du Cancer·W Z WeiR F Jones
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·F Vidal-VanaclochaC A Dinarello
Oct 20, 2001·The Journal of Biological Chemistry·Richard C D'AlonzoNicola C Partridge
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·David Levens
Apr 10, 2003·Journal of Veterinary Internal Medicine·Dennis BaileyMarlene Hauck
Jan 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dingzhi Wang, Raymond N DuBois
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Sep 27, 2005·Research in Veterinary Science·Birgitt WolfesbergerMonika Egerbacher
Oct 18, 2005·Nature Reviews. Molecular Cell Biology·Michele Boiani, Hans R Schöler
Jun 15, 2007·Cancer Biology & Therapy·Yuichiro OshimaTakashi Tokino
Apr 29, 2008·Nature Medicine·Greg FinakMorag Park
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitsuru MiyachiHajime Hosoi
Dec 2, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Minyoung LimPradip Roy-Burman
Mar 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard Gorlick, Chand Khanna
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Sep 9, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christophe Le TourneauEric Raymond
Aug 13, 2011·Cancer·Simona OgnjanovicPierre Hainaut
Jan 26, 2012·International Journal of Cancer. Journal International Du Cancer·Lin WangChia-Ying Lin
Feb 24, 2012·BMC Veterinary Research·Rose Eli Grassi RiciDurvanei Augusto Maria
Sep 13, 2012·Experimental and Therapeutic Medicine·Ichiro OtaTakeo Ohnishi
Apr 25, 2014·Molecular Cancer Research : MCR·Tetsuro OhbaJonathan G Schoenecker
Jun 18, 2014·ILAR Journal·Joelle M FengerWilliam C Kisseberth
Oct 25, 2014·Drug Design, Development and Therapy·Maria Cekanova, Kusum Rathore
Nov 26, 2014·Veterinary Research Communications·M SzewczykK Zabielska
Mar 5, 2015·Anti-cancer Agents in Medicinal Chemistry·Na LiQiping Zheng
Aug 8, 2015·Cancer Biology & Therapy·Cédric CastrogiovanniPatrick Dumont
Feb 3, 2016·Oncology Letters·Jia WanXiangsheng Zhang

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Citations

Feb 23, 2019·Journal of Cellular Physiology·Mudasir Bashir GugjooGutulla Taru Sharma
Jun 2, 2020·Journal of Veterinary Science·Min Hee Kang, Hee Myung Park

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