Combination Therapy of Clinically Approved Antifungal Drugs Is Enhanced by Conjugation with Silver Nanoparticles

International Microbiology : the Official Journal of the Spanish Society for Microbiology
Muhammad Asim HussainNaveed Ahmed Khan

Abstract

Silver nanoparticles (SN) have been recently developed as a new class of antimicrobial agents against numerous pathogenic microorganisms. SN have also been used as efficient drug delivery systems and have been linked with increasing drug potency. Here, we demonstrated the enhanced antifungal efficacy of nystatin (NYT) and fluconazole (FLU) after conjugation with SN. The antifungal bioactivity of NYT- and FLU-coated SN was evaluated against Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 by the agar tube dilution method. The aim of this study was to determine and compare the antifungal efficacy of NYT and FLU with their SN and, finally, the combination of both nanoparticles as NYT-SN + FLU-SN against pathogenic fungi. The results indicated that all test samples showed a dose-dependent response against tested fungi. SN significantly enhanced the antifungal effects of NYT and FLU as compared to drugs alone. We observed a remarkable increase in the percent inhibition of both fungi (90-100%) when treated with a combination of both nanoparticles NYT-SN + FLU-SN at 200 μg/mL only. Furthermore, the morphological modifications occurred at the surface of fungal species were also analyzed by atomic force microscopy (AF...Continue Reading

References

Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A Espinel-Ingroff, S Shadomy
Mar 1, 1996·The Journal of Hospital Infection·K W LoudonC Q Morris
May 26, 2004·Journal of Colloid and Interface Science·Ivan Sondi, Branka Salopek-Sondi
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Oct 4, 2008·The Journal of Physical Chemistry. B·C CarlsonJ J Schlager
Oct 16, 2008·Biotechnology Advances·Mahendra RaiAniket Gade
Jul 8, 2009·International Journal for Parasitology·Naveed Ahmed Khan, Ruqaiyyah Siddiqui
Aug 25, 2009·Biomaterials·Ales PanácekLibor Kvítek
Dec 18, 2009·Current Medicinal Chemistry·L ZhangC-M Huang
Mar 20, 2010·Journal of Medical Microbiology·A K PersonJ E Stout
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ae Jung Huh, Young Jik Kwon
Aug 2, 2011·Microbes and Infection·Julian R NaglikBernhard Hube
Mar 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara D AlexanderMichael A Pfaller
Apr 24, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M C ArendrupH C Schønheyder
Oct 10, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E VermeulenK Lagrou
May 3, 2014·Cold Spring Harbor Perspectives in Medicine·Terry Roemer, Damian J Krysan
Jun 6, 2014·BioMed Research International·Samer Hasan Hussein-Al-AliMohd Zobir Hussein
Jun 14, 2017·Antimicrobial Agents and Chemotherapy·Shashwat MalhotraNigel G J Richards

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Citations

Feb 5, 2021·Expert Opinion on Pharmacotherapy·Liliana ScorzoniEleftherios Mylonakis
May 25, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Dongmei Jia, Wenping Sun
Dec 29, 2021·Recent Advances in Anti-infective Drug Discovery·Ensieh LotfaliMohammad Mahdi Rabiei

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Methods Mentioned

BETA
surface plasmon resonance
atomic force microscopy
AFM

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