PMID: 7013960Feb 1, 1981Paper

Combination therapy of hormone and cytotoxic agents in advanced breast cancer

Cancer
D T KiangB J Kennedy

Abstract

The effectiveness of combination therapy with diethylstilbestrol, cyclophosphamide, and 5-fluorouracil (DES + CTx + FU) was compared with DES alone or CTx + FU in 87 postmenopausal women with advanced breast cancer. Therapy was randomized according to the tumor estrogen-receptor (ER) status. In 30 patients with ER-rich tumors and 35 patients with ER-unknown tumors, combination therapy yielded a higher response rate than DES therapy (87% vs. 64% and 59% vs. 23%, respectively). The pooled data from these two groups of patients suggest that the improved response rate from DES + CTx + FU against DES becomes more apparent in patients with visceral involvement (89% vs. 47%) (P less than 0.025) and that patients treated initially with combination therapy (DES + CTx + FU) appeared to have a longer survival than those treated with sequential therapy (DES leads to CTx + FU) (P = 0.06). The survival data in 22 patients with receptor-poor tumors were significantly inferior to those with receptor-rich tumors (P = 0.001). The ER status and presence of visceral metastases are significant factors in the selection of treatment programs.

References

Jan 1, 1975·Medical and Pediatric Oncology·S G TaylorT C Hall
Oct 1, 1977·Cancer·D T Kiang, B J Kennedy
Jan 1, 1975·Medical and Pediatric Oncology·B J Kennedy, D T Kiang

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Citations

Jan 1, 1981·Breast Cancer Research and Treatment·D T Kiang, B J Kennedy
Jan 1, 1984·Breast Cancer Research and Treatment·M E Lippman
Dec 1, 1985·Journal of Steroid Biochemistry·M R SertoliR Rosso
Jul 27, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Matthieu HureauClaude Brémard
Nov 14, 1985·The New England Journal of Medicine·D T KiangB J Kennedy
Aug 1, 1985·Seminars in Oncology Nursing·C L Vogel
Jan 15, 1990·Cancer·D T KiangB J Kennedy

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