Combination therapy of oral fluoropyrimidine anticancer drug S-1 and interferon alpha for HCC patients with extrahepatic metastases

Oncology
Kiminori UkaK Chayama

Abstract

There is no standard treatment for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. We assessed the efficiency and safety of the oral fluoropyrimidine anticancer drug S-1 combined with interferon alpha (IFN-alpha) for HCC patients with extrahepatic metastases. Twenty-nine HCC patients with extrahepatic metastases received S-1/IFN. One cycle of combination therapy represented 2 weeks followed by 2-4 weeks of rest. In each cycle, S-1 was administrated orally at 80-120 mg (depending on body surface area) every day and IFN-alpha intramuscularly at 5 million units thrice weekly. The overall response of 29 patients was complete response (CR) in 4 (14%), partial response (PR) in 1, stable disease in 4, progressive disease in 12, and dropout in 8 patients. Objective response (CR + PR) was 17%. The time to progression and survival rate were significantly higher in patients with lung metastases (n = 19) than in those with painful bone metastases (n = 7; p = 0.0058 and 0.0015). With regard to NCI-CTC grade 3 adverse reactions, 3 (10%), 3 (10%) and 2 (7%) patients developed anorexia, leukopenia, and neutropenia, respectively. No grade 4 adverse reaction or toxicity-related death occurred. S-1/IFN is a potentially safe ...Continue Reading

Citations

Mar 10, 2010·Journal of Cancer Research and Clinical Oncology·Peng-Yuan ZhuangHui-Chuan Sun
Jan 31, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshio KatamuraKazuaki Chayama
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroshi SadamoriToshiyoshi Fujiwara
Jul 22, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yohji HondaKazuaki Chayama
Nov 20, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yohji HondaKazuaki Chayama
Mar 19, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norihito NakanoKazuaki Chayama
Apr 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Rong WuShi-Bing Su

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