Combination therapy of transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for small hepatocellular carcinoma: comparison with TACE or RFA monotherapy

Abdominal Radiology
Wooil KimHyunchul Rhim

Abstract

To compare the safety and efficacy of combined transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC) with those of TACE or RFA monotherapy. This study included 34 combined TACE and RFA (TACE-RFA), 87 TACE, and 136 ultrasound-guided RFA, which were performed to treat HCC (≤ 3 cm, 3 or fewer) between March and August 2009. The safety (Child-Pugh score indicating hepatic functional reserve, patient discomfort requiring medication, duration of hospitalization, and complications) and efficacy (1-month, 6-month, and 1-year tumor responses) profiles of each treatment were evaluated and compared. TACE-RFA group showed longer hospital stay and more frequent patient discomfort requiring medication than TACE or RFA group (P < 0.001). The frequency of overall complications after TACE-RFA was higher than TACE (P = 0.006) or RFA (P = 0.009). There were no statistical differences in major complication rates between the three groups (P = 0.094). Child-Pugh score at 1-month follow-up showed no significant difference between the three groups (P = 0.162). 1-month, 6-month, and 1-year tumor responses of TACE-RFA were similar to those of RFA and better than those of TACE. TACE-RFA appears ...Continue Reading

References

Sep 25, 2002·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kazuya SugimoriKatsuaki Tanaka
Dec 10, 2002·Journal of Vascular and Interventional Radiology : JVIR·Koichiro YamakadoKan Takeda
Mar 17, 2004·World Journal of Surgery·Ming ShiJin-Qing Li
May 12, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masahiko KodaYoshikazu Murawaki
Dec 30, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Marco MontorsiMara Costa
Sep 7, 2007·Journal of Vascular and Interventional Radiology : JVIR·Young-Sun KimSeung Hoon Kim
Feb 3, 2009·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Tae Wook KangHyo K Lim
Jul 9, 2009·Journal of Vascular and Interventional Radiology : JVIR·S Nahum GoldbergUNKNOWN Society of Interventional Radiology Technology Assessment Committee and the International Working Group on Image-guided Tumo
Jul 9, 2009·Journal of Vascular and Interventional Radiology : JVIR·Daniel B BrownUNKNOWN Society of Interventional Radiology Technology Assessment Committee and the International Working Group on Image-Guided Tumo
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Apr 22, 2010·Digestion·Argyro FassoulakiAikaterini Melemeni
Nov 8, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qing-Feng KongBin Lv
Apr 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenyin LiuRijie Tang
Sep 26, 2014·World Journal of Gastroenterology : WJG·Won Hyeok ChoeSo Young Kwon
May 27, 2016·The Cochrane Database of Systematic Reviews·Rachael PowellMarie Johnston

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Citations

Dec 20, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Lei WangJingfeng Liu
Aug 28, 2019·Digestive Diseases and Sciences·David E Kaplan
Sep 2, 2019·Surgical Oncology Clinics of North America·Benjamin L Green, Michael G House
Feb 27, 2021·Transplantation Reviews·Guangjiang JiangXiao Xu
Mar 12, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Zhaonan LiZaoqu Liu
Jun 15, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Xuqi SunMing Zhao
Dec 24, 2021·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Shoujin CaoJian Wang

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