Combination therapy with albumin and pentoxifylline protects against acute kidney injury during endotoxemic shock in mice

Renal Failure
Shweta BansalRobert Schrier

Abstract

Endotoxemic shock is associated with approximately 50% incidence of acute kidney injury (AKI) and 70% mortality. Experimental studies indicate that endotoxemia-related AKI is associated with both hemodynamic and proinflammatory perturbations. We hypothesize that combined administration of albumin with pentoxifylline may protect against the development of AKI during endotoxemic shock in mice by maintaining the integrity of arterial circulation and exerting anti-inflammatory properties. We tested this hypothesis using an endotoxemic shock model produced by administering a high dose of lipopolysaccharide (LPS) (15 mg/kg intraperitoneal). LPS-treated mice developed hypotension compared to control mice (mean arterial pressure [MAP] 65.6 +/- 2.2 vs. 85.7 +/- 0.8 mm Hg, p < 0.05). Normal saline did not attenuate LPS-related hypotension (62.7 +/- 2.2 vs. 65.6 +/- 2.2 mm Hg, NS). Pentoxifylline, a phosphodiesterase inhibitor, worsened the LPS-related hypotension (50.7 +/- 6.9 vs. 65.6 +/- 2.2 mm Hg, p = 0.15) in a non-significant manner. Albumin alone caused a significant increase in MAP (79.3 +/- 4.7 vs. 62.7 +/- 2.2 mm Hg, p = 0.02), but had a non-significant modest effect on glomerular filtration rate (GFR; 60.8 +/- 24.7 vs. 38.2 +/-...Continue Reading

References

Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·L YuR W Schrier
Jan 11, 1995·JAMA : the Journal of the American Medical Association·M S Rangel-FraustoR P Wenzel
Nov 1, 1994·The American Journal of Cardiology·C J Fernandes JúniorE Knobel
Apr 18, 2000·Critical Care Clinics·A KumarJ E Parrillo
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick N CunninghamRichard J Quigg
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Wei WangRobert W Schrier
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jose IglesiasUNKNOWN Norasept II Study Investigators
May 28, 2004·The New England Journal of Medicine·Simon FinferUNKNOWN SAFE Study Investigators
Jul 13, 2004·The New England Journal of Medicine·Robert W Schrier, Wei Wang
Nov 16, 2004·Critical Care Medicine·Jean-Louis Vincent, Herwig Gerlach
Sep 21, 2006·American Journal of Physiology. Renal Physiology·Wei WangRobert Schrier
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Ganesan RameshW Brian Reeves

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Citations

Mar 5, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Sylvia GruberWolfgang Dörr
May 18, 2013·The Korean Journal of Internal Medicine·Shailendra Kapoor
Jun 30, 2012·The Journal of Trauma and Acute Care Surgery·Ziqing HeiXiaoyun Li

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