PMID: 9174196Jun 1, 1997Paper

Combination therapy with amphotericin B and fluconazole against invasive candidiasis in neutropenic-mouse and infective-endocarditis rabbit models

Antimicrobial Agents and Chemotherapy
H SanatiM A Ghannoum

Abstract

Although there are an increasing number of new antifungal agents available, the morbidity and mortality due to invasive mycoses remain high. The high rates of polyene toxicities and the development of azole resistance have raised the issue of using antifungal agents of these classes in combination, despite theoretical concerns regarding antagonism between such agents. This study was designed to evaluate the in vivo efficacy of combined therapy with amphotericin B and fluconazole against Candida albicans. Two distinct animal models were used in this study: a neutropenic-mouse model of hematogenously disseminated candidiasis and the infective-endocarditis rabbit model. Treatment efficacy was assessed by determining reductions in mortality as well as decreases in tissue fungal densities. In the neutropenic-mouse model, amphotericin B, as well as combination therapy, significantly prolonged survival compared to untreated controls (P < 10(-5) and P = 0.001, respectively). The fungal densities in the kidneys of neutropenic mice were significantly reduced with either amphotericin B monotherapy or amphotericin B-fluconazole combined therapy compared to those of controls (P < 10(-6)). Fluconazole monotherapy also reduced fungal densitie...Continue Reading

References

Mar 1, 1990·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·R Sabra, R A Branch
Mar 1, 1990·Reviews of Infectious Diseases·H A GallisW W Pickard
Jul 1, 1989·Infection·A Polak
Jan 1, 1988·Antimicrobial Agents and Chemotherapy·M S Saag, W E Dismukes
Mar 1, 1988·Antimicrobial Agents and Chemotherapy·R M TuckerD A Stevens
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·A M SugarM Picard
Feb 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ReddingM Pfaller
Jan 27, 1994·The New England Journal of Medicine·J A Como, W E Dismukes
Sep 1, 1993·The Journal of Infectious Diseases·D GeorgeV T Andriole
Sep 1, 1995·Antimicrobial Agents and Chemotherapy·A M Sugar
Nov 1, 1995·Antimicrobial Agents and Chemotherapy·M A GhannoumR S Criddle

❮ Previous
Next ❯

Citations

Apr 17, 2001·Antimicrobial Agents and Chemotherapy·F BarchiesiJ R Graybill
Jun 25, 2003·Antimicrobial Agents and Chemotherapy·Ruth C MatthewsJames Burnie
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Francesco BarchiesiGiorgio Scalise
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Francesco BarchiesiGiorgio Scalise
Feb 26, 2004·Antimicrobial Agents and Chemotherapy·Melissa D JohnsonJohn H Rex
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·William R KirkpatrickThomas F Patterson
Sep 18, 2004·The Journal of Antimicrobial Chemotherapy·Manuel Cuenca-Estrella
Jan 18, 2005·Clinical Microbiology Reviews·Pranab K MukherjeeMahmoud A Ghannoum
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Anthony CacciapuotiDavid Loebenberg
Mar 3, 2018·Journal of Fungi·Mobaswar Hossain ChowdhuryGill Diamond
Aug 22, 2000·Antimicrobial Agents and Chemotherapy·F BarchiesiG Scalise
Jul 31, 2007·Future Microbiology·Jose A Vazquez
Feb 10, 2021·Journal of Fungi·Anne-Laure BidaudEric Dannaoui
Jun 20, 1998·Clinical Microbiology Reviews·T C WhiteR A Bowden
Jan 9, 1999·Clinical Microbiology Reviews·D J SheehanC M Sibley
Jun 28, 2003·Trends in Molecular Medicine·Antonella LupettiRomano Danesi
Dec 9, 2003·International Journal of Antimicrobial Agents·Maria Jimenez-ValeraAlfonso Ruiz-Bravo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.