Combination therapy with didanosine and interferon-alpha in human immunodeficiency virus-infected patients: results of a phase I/II trial

The Journal of Infectious Diseases
Joseph A KovacsH Clifford Lane

Abstract

A nonrandomized trial was undertaken to evaluate the combination of didanosine and interferon-alpha (INF-alpha) in human immunodeficiency virus (HIV)-infected patients. Thirty-six volunteers with >200 x 10(6) CD4 cells/L received didanosine (one 100-, 250-, or 375-mg sachet twice daily) for at least 6 weeks, following which IFN-alpha (1, 5, 10, or 15 MU/day) was begun. Didanosine (one 375-mg sachet twice daily) was substituted for zidovudine in 14 additional patients who had received IFN-alpha and zidovudine for 7-45 months. Thirty-five patients completed the 34-week study. Clinical or chemical pancreatitis was the most common (6 patients) dose-limiting toxicity. CD4 cell counts increased with didanosine but declined following the addition of IFN-alpha; CD4 cell percents tended to increase and remain elevated. Thus, combination therapy with didanosine and IFN-alpha can be safely administered to patients with HIV infection. The clinical benefit of this combination therapy will require further evaluation.

Citations

Mar 1, 1971·In Vitro·N P Salzman
May 15, 2002·Archives of Pharmacal Research·Henry J LeeDong-Hoon Ko
Feb 27, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter L AndersonKenneth A Lichtenstein
Nov 3, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Barbara McGovernIoana Bica
Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A HatzakisC Stalgis
Oct 21, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pierre CordelierDavid S Strayer
Nov 13, 2002·Journal of Hematotherapy & Stem Cell Research·Pierre CordelierDavid S Strayer
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dessislava I DimitrovaRobert J Suhadolnik
Nov 10, 2009·AIDS·Jonathan B AngelEdwin DeJesus
Sep 12, 2006·Médecine sciences : M/S·Yves Lévy
Jun 30, 2012·Cytokine & Growth Factor Reviews·Sheila M KeatingPhilip J Norris
Mar 10, 2000·AIDS Research and Human Retroviruses·D W HaasJ Rooney
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin GibbertUlf Dittmer
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Curtis L Cooper, D William Cameron
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Barbara McGovern, Ioana Bica

❮ Previous
Next ❯

Related Concepts

Related Feeds

Buruli Ulcer

Buruli ulcer is a progressive disease of subcutaneous tissues caused by mycobacterium ulcerans. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.