Combination therapy with nifedipine GITS 60 mg: subanalysis of a prospective, 12-week observational study (AdADOSE)

Clinical and Experimental Hypertension : CHE
Ahmed K MotaweihThomas Petri

Abstract

AdADOSE was a 12-week, international, observational study conducted in the Middle East and Russia where patients received nifedipine gastrointestinal therapeutic system (GITS) at a daily dose of 30, 60, or 90 mg as part of an antihypertensive combination therapy. This subgroup analysis of the AdADOSE study assesses the efficacy and tolerability of nifedipine GITS combination therapy when used specifically at the 60-mg strength. Patients with hypertension who received a daily nifedipine GITS dose of 60 mg, either at constant dose (n = 686) or up-titrated from 30 mg (n = 392), were analyzed. Target blood pressure (BP) was <140/90 mmHg (or <130/80 mmHg for those at high/very high cardiovascular risk). Following nifedipine GITS combination therapy, target BP was achieved by 33.7% patients in the 60 mg group (previously untreated, 42.5%; previously treated, 32.0%) and 32.4% patients in the 30-60 mg group (previously untreated, 45.2%; previously treated, 30.7%). Mean systolic BP/diastolic BP changes were -40.3/-20.7 mmHg and -35.6/-18.5 mmHg, respectively, and were similar regardless of previous antihypertensive treatment or the number of concomitant diseases. Incidences of drug-related adverse events (AEs) were low (3.2%, 60 mg; 2.0...Continue Reading

References

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Sep 8, 2004·Lancet·Philip A Poole-WilsonUNKNOWN Coronary disease Trial Investigating Outcome with Nifedipine gastrointestinal therapeutic system investigators
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ikuo SaitoUNKNOWN ADVANCE-Combi Study Group
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Apr 20, 2010·Journal of the American Society of Hypertension : JASH·Alan H GradmanMichael A Weber
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Clinical Trials Mentioned

NCT01118286

Software Mentioned

AdADOSE

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