Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer's disease.

The Journal of Biological Chemistry
Takashi MoriTerrence Town

Abstract

To date, there is no effective Alzheimer's disease (AD)-modifying therapy. Nonetheless, combination therapy holds promise, and nutraceuticals (natural dietary compounds with therapeutic properties) and their synthetic derivatives are well-tolerated candidates. We tested whether combination therapy with octyl gallate (OG) and ferulic acid (FA) improves cognition and mitigates AD-like pathology in the presenilin-amyloid β-protein precursor (PSAPP) transgenic mouse model of cerebral amyloidosis. One-year-old mice with established β-amyloid plaques received daily doses of OG and FA alone or in combination for 3 months. PSAPP mice receiving combination therapy had statistically significant improved cognitive function versus OG or FA single treatment on some (but not all) measures. We also observed additional statistically significant reductions in brain parenchymal and cerebral vascular β-amyloid deposits as well as brain amyloid β-protein abundance in OG- plus FA-treated versus singly-treated PSAPP mice. These effects coincided with enhanced nonamyloidogenic amyloid β-protein precursor (APP) cleavage, increased α-secretase activity, and β-secretase inhibition. We detected elevated expression of nonamyloidogenic soluble APP-α and th...Continue Reading

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Citations

Aug 14, 2018·Current Drug Targets·Duraiswamy BasavanMohan K S Kumar
Jun 23, 2019·Journal of Alzheimer's Disease : JAD·Elizabeth Kurudamannil George, P Hemachandra Reddy
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Sabrina PicocciGianfranco Gennarini
Oct 2, 2019·Food Science & Nutrition·Akihiro YamauchiEiichi Hirano
Feb 11, 2021·Nutrients·Piotr LondzinJoanna Folwarczna
Jan 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hironao NakayamaKiyoyuki Kitaichi
Oct 13, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ningbo WangHongyu Li
Jun 23, 2021·Bioorganic & Medicinal Chemistry·Igri KolajDonald F Weaver
Sep 24, 2021·Journal of Agricultural and Food Chemistry·Hui XuMingfu Wang

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