PMID: 18705531Aug 19, 2008Paper

Combination therapy with valsartan/hydrochlorothiazide at doses up to 320/25 mg improves blood pressure levels in patients with hypertension inadequately controlled by valsartan 320 mg monotherapy

Blood Pressure. Supplement
Jaakko TuomilehtoPhilippe Ferber

Abstract

To investigate the efficacy and tolerability of valsartan (Val) 320 mg once daily (o.d.), Val/hydrochlorothiazide (HCTZ) 320/12.5 mg o.d. and Val/HCTZ 320/25 mg o.d. in patients with hypertension not adequately controlled by Val monotherapy. This double-blind, active-controlled, parallel-group, randomized trial recruited patients > or =18 years with mild-to-moderate essential hypertension, defined as mean sitting diastolic blood pressure (MSDBP) of > or =95 mmHg and <110 mmHg without treatment. After washout, 3805 eligible patients received Val 320 mg o.d. single-blind for 4 weeks. Subsequently, patients with MSDBP > or =90 and <110 mmHg (n=2702) were randomized to double-blind treatment with Val 320 mg, Val/HCTZ 320/12.5 mg or Val/HCTZ 320/25 mg for 8 weeks. Mean changes in MSDBP and mean sitting systolic BP (MSSBP) from the start of the single-blind period were analysed, as well as the proportion of responders (MSDBP <90 mmHg or > or =10 mmHg decrease from the start of the double-blind period). Tolerability and safety were also assessed. Reductions in MSDBP and MSSBP were observed in all groups. Both combinations were associated with significantly greater reductions than monotherapy for MSDBP and MSSBP at Weeks 8 and 12 (all ...Continue Reading

References

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Citations

Aug 20, 2009·Expert Opinion on Drug Metabolism & Toxicology·Robyn Kondrack, Syed Mohiuddin
Aug 6, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gianfranco ParatiThomas Mengden
Apr 15, 2011·International Journal of Clinical Practice·D RichterC Militaru
Dec 15, 2010·Expert Opinion on Drug Safety·Roberto Fogari, Annalisa Zoppi

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