Combination use of nonsteroidal antiinflammatory drugs

Drug Intelligence & Clinical Pharmacy
D R Miller

Abstract

Polypharmacy with nonsteroidal antiinflammatory drugs (NSAIDs) is widely practiced despite being condemned by many rheumatologist. Combination use of aspirin with other NSAIDs might be discouraged for three well-documented reasons. First, aspirin reduces the blood levels of many NSAIDs. Second, multiple drugs are antagonistic or at least less than additive in animal models of inflammation. Third, there is no good clinical data to suggest that combination use of NSAIDs is beneficial. Unless new studies become available, NSAIDs should be used one at a time, with supplementary analgesics added on a prn basis.

References

Jan 1, 1977·Current Medical Research and Opinion·P M Brooks, T K Khong
May 1, 1979·Journal of Clinical Pharmacology·D C Hobbs, T M Twomey
Oct 1, 1977·Scottish Medical Journal·J A RennieH A Capell
Nov 1, 1979·British Journal of Clinical Pharmacology·D M GrennanM Mackinnon
Mar 1, 1979·Arthritis and Rheumatism·R P KimberlyM D Lockshin
Oct 28, 1978·British Medical Journal·R D Brandstetter, D D Mar
Dec 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K C KwanD E Duggan
Jul 1, 1976·Arthritis and Rheumatism·R F Willkens, E J Segre
Oct 1, 1975·Clinical Pharmacology and Therapeutics·E H WisemanD C Hobbs
Jul 12, 1975·British Medical Journal·P M BrooksA R Rhymer
Feb 28, 1975·European Journal of Clinical Pharmacology·J C GarnhamP Turner
Feb 1, 1976·Clinical Pharmacology and Therapeutics·W A CressmanJ Plostnieks
Jul 1, 1968·The Journal of Pharmacy and Pharmacology·Z E MielensV J Sansone
Oct 26, 1974·British Medical Journal·E C Huskisson
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·P WarrickC M Gruber
Mar 1, 1972·Clinical Pharmacology and Therapeutics·G D ChampionC M Pearson
Sep 1, 1973·Arthritis and Rheumatism·A RubinA S Ridolfo
Mar 1, 1974·Clinical Pharmacology and Therapeutics·B LindquistT Hansen
Apr 1, 1974·Clinical Pharmacology and Therapeutics·E J SegreH Sevelius
Jan 1, 1968·Clinical Pharmacology and Therapeutics·W M O'Brien
Jul 18, 1970·The Medical Journal of Australia·R Jeremy, J Towson
Jan 12, 1980·British Medical Journal·I Caruso, G Bianchi Porro

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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·E Zylber-KatzM Levy
Jan 1, 1984·Drug Intelligence & Clinical Pharmacy·R S Porter
Jan 1, 1993·Arthritis and Rheumatism·J G Schaller
Jan 1, 1989·European Journal of Clinical Pharmacology·A Van HeckenP J De Schepper
Nov 1, 1982·Journal of the American Geriatrics Society·P C Johnson
Mar 1, 1982·British Journal of Clinical Pharmacology·S R RudgeI D Hind
Jan 1, 1983·Scandinavian Journal of Rheumatology·J Martio, P Kahela

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