Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation.

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Roongruedee ChaiteerakijLewis R Roberts

Abstract

Growing evidence suggests that pretransplant alpha-fetoprotein (AFP) predicts outcomes of hepatocellular carcinoma (HCC) patients treated with liver transplantation. We aimed to determine whether pretransplant AFP, Lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3), and des-gamma-carboxyprothrombin (DCP) predicted HCC recurrence after transplantation. A retrospective cohort study of 313 HCC patients undergoing transplantation between 2000 and 2008 was conducted, and 48 (15.3%) developed recurrence during a median follow-up of 90.8 months. The 127 patients with available serum drawn before transplantation were included; they included 86 without recurrence and 41 with recurrence. Serum was tested for AFP, AFP-L3%, and DCP in a blinded fashion with the μTASWako i30 immunoanalyzer. All biomarkers were significantly associated with HCC recurrence. The hazard ratios (HRs) were 3.5 [95% confidence interval (CI), 1.9-6.7; P < 0.0001] for DCP ≥ 7.5 ng/mL and 2.8 (95% CI, 1.4-5.4; P = 0.002) for AFP ≥ 250 ng/mL. The HR increased to 5.2 (95% CI, 2.3-12.0; P < 0.0001) when AFP ≥ 250 ng/mL and DCP ≥7.5 ng/mL were considered together. When they were combined with the Milan criteria, the HR increased from 2.6 (95% CI, 1.4-4.7; P = ...Continue Reading

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Citations

Oct 13, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Joel P WeddScott W Biggins
Sep 29, 2015·Future Oncology·Alessandra MazzolaGiuseppe Cabibbo
Sep 4, 2015·Current Hepatology Reports·Maria E LozadaLewis R Roberts
Mar 27, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hae Won LeeKyung-Suk Suh
Nov 13, 2018·Journal of Cellular Biochemistry·Nashwa El-KhazragyMarwa Hegazy
Jan 13, 2016·World Journal of Gastroenterology : WJG·Umberto CilloAlessandro Vitale
Feb 27, 2016·Current Opinion in Organ Transplantation·Hae Won Lee, Kyung-Suk Suh
Jan 26, 2016·Current Opinion in Organ Transplantation·Neil Mehta, Francis Y Yao
Sep 17, 2020·Expert Review of Gastroenterology & Hepatology·Daniel Hoffman, Neil Mehta
Feb 2, 2019·World Journal of Hepatology·Maria J CitoresValentin Cuervas-Mons
Nov 18, 2015·World Journal of Gastroenterology : WJG·René FahrnerFalk Rauchfuß
Jun 7, 2019·Clinical Liver Disease·Neil Mehta, Francis Y Yao
Nov 12, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elizabeth C VernaFrancis Y Yao
Nov 1, 2017·Current Hepatology Reports·Hager F Ahmed Mohammed, Lewis R Roberts
Mar 7, 2020·Hepatology Communications·Neil Mehta
Feb 2, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Prashant KotwaniNeil Mehta
Oct 6, 2020·Clinics in Liver Disease·Kali Zhou, Neil Mehta
May 13, 2021·Clinics in Liver Disease·Allison Kwong, Neil Mehta
May 20, 2021·Journal of Clinical and Translational Hepatology·Leana Frankul, Catherine Frenette
Jun 13, 2021·Journal of Cancer Research and Clinical Oncology·Abu Bakar Hafeez BhattiAtif Rana

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