Combinations of monoclonal antibodies can distinguish primary lung tumors from metastatic lung tumors sampled by fine needle aspiration biopsy.

Cancer
M MottoleseP G Natali

Abstract

Transthoracic fine needle aspiration (FNA) biopsies performed under computed tomography (CT) scan (CT-FNA) have greatly improved the cytodiagnosis of lung tumors. However, the distinction between a primary lesion and a metastatic lesion still may be difficult on the basis of morphologic criteria. To evaluate whether a selected panel of monoclonal antibodies (MoAb) to tumor-associated antigens (TAA) can improve the diagnostic potential of FNA, we have immunocytochemically analyzed 122 pulmonary CT-FNA. Whereas conventional cytology was capable of recognizing only the neoplastic nature of the lesions, the immunocytochemical diagnosis could identify the primary or metastatic nature of the pulmonary masses in 92.5% of the cases. The immunocytochemical findings were confirmed by clinical-histopathologic data. The current results demonstrate that the use of immunocytochemical methods can significantly improve the diagnostic accuracy of conventional cytology of lung masses.

References

Mar 15, 1987·International Journal of Cancer. Journal International Du Cancer·S MiottiM I Colnaghi
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·R MuraroJ Schlom
May 15, 1987·International Journal of Cancer. Journal International Du Cancer·J M KaldorF E Neal
Feb 1, 1987·Radiology·J H StanleyS I Schabel
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Dec 16, 1983·Journal of Immunological Methods·C RussoS Ferrone
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D ColcherJ Schlom
Nov 1, 1981·The Journal of Clinical Investigation·R C BastR C Knapp

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Citations

Feb 1, 1991·Cytotechnology·A BartolazziG A Giorgio Natali
Jan 1, 1989·Current Opinion in Immunology·P G Natali, A G Siccardi
Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·M MottoleseP G Natali
Jan 1, 1993·Journal of Clinical Laboratory Analysis·M MottoleseP G Natali

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