PMID: 9182799May 1, 1997Paper

Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging

Neuron
Rainer W Friedrich, Sigrun I Korsching

Abstract

Odors are thought to be represented by a distributed code across the glomerular modules in the olfactory bulb (OB). Here, we optically imaged presynaptic activity in glomerular modules of the zebrafish OB induced by a class of natural odorants (amino acids [AAs]) after labeling of primary afferents with a calcium-sensitive dye. AAs induce complex combinatorial patterns of active glomerular modules that are unique for different stimuli and concentrations. Quantitative analysis shows that defined molecular features of stimuli are correlated with activity in spatially confined groups of glomerular modules. These results provide direct evidence that identity and concentration of odorants are encoded by glomerular activity patterns and reveal a coarse chemotopic organization of the array of glomerular modules.

References

Jun 15, 1979·The Journal of Comparative Neurology·W B StewartG M Shepherd
Oct 22, 1992·The Journal of Comparative Neurology·D R Riddle, B Oakley
Feb 15, 1990·Nature·R Durbin, G Mitchison
Aug 1, 1988·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W B Mathieson, L Maler
Jul 8, 1966·Science·J Leveteau, P MacLeod
Sep 17, 1984·Brain Research·G D AdamekB Oakley
Jan 1, 1983·Tissue & Cell·P Cancalon
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D LancetG M Shepherd
Feb 1, 1980·Acta Physiologica Scandinavica·K B DøvingG Thommesen
Oct 1, 1995·Scientific American·R Axel
Jan 1, 1995·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W C Michel, L M Lubomudrov
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·M YokoiS Nakanishi
Aug 1, 1994·Current Opinion in Neurobiology·K J ResslerL B Buck
Feb 1, 1993·Microscopy Research and Technique·J W ScottN Buonviso
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M GuthrieC Gall
Jan 1, 1996·Annual Review of Neuroscience·L B Buck
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·F WethS Korsching
Nov 15, 1996·Cell·P MombaertsR Axel
Dec 17, 1997·Cephalalgia : an International Journal of Headache·R D Snyder, P D Drummond

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Citations

Sep 12, 2000·The Journal of Comparative Neurology·B A Johnson, M Leon
May 7, 2002·Journal of Neuroscience Research·J DuK A Hamilton
Mar 19, 2009·Cellular and Molecular Life Sciences : CMLS·Michael Leon, Brett A Johnson
Dec 28, 2012·Cellular and Molecular Life Sciences : CMLS·Sebastian GliemIvan Manzini
Oct 28, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Anthony Leonardo
May 6, 2011·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Peter C HubbardAdelino V M Canário
Jul 30, 2005·Cellular and Molecular Neurobiology·Bradley J BakerDejan Zecevic
Jun 24, 2009·Journal of Computational Neuroscience·Mainak PatelDavid Cai
Aug 29, 2009·Journal of Computational Neuroscience·Stuart D WickHermann Riecke
Dec 31, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ilia BrondzKjell Døving
Aug 6, 1999·Brain Research·K S Wekesa, R R Anholt
Aug 2, 2002·European Journal of Pharmacology·Fritjof Helmchen, Jack Waters
Aug 30, 2003·Neuroscience and Biobehavioral Reviews·Donald A Wilson, Richard J Stevenson
Aug 23, 2001·Brain Research. Brain Research Reviews·F Laberge, T J Hara
Aug 17, 2001·Trends in Neurosciences·J R Carlson
Sep 11, 2002·Trends in Neurosciences·Rainer W Friedrich
May 15, 2003·Trends in Neurosciences·Donald A Wilson, Richard J Stevenson
Apr 13, 1999·Trends in Neurosciences·T K AlkasabJ S Kauer
Sep 12, 2000·Current Opinion in Neurobiology·C G Galizia, R Menzel
Aug 15, 2001·Current Opinion in Neurobiology·R W Friedrich, M Stopfer
Jul 26, 2002·Current Opinion in Neurobiology·Sigrun Korsching
Feb 21, 2003·Current Opinion in Neurobiology·Andreas Keller, Leslie B Vosshall
Sep 30, 1998·Current Opinion in Neurobiology·F A Ebrahimi, A Chess
Sep 30, 1998·Current Opinion in Neurobiology·P W SorensenN E Stacey
May 5, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Frédéric Laberge, Toshiaki J Hara
Nov 15, 2011·ACS Chemical Neuroscience·Baranidharan RamanSteve Semancik
Jan 20, 2009·Nature Neuroscience·Edward R SoucyMarkus Meister
Jan 28, 2009·Nature Neuroscience·Nathan E Schoppa
Jul 27, 2004·Nature Neuroscience·Rainer W FriedrichGilles Laurent
Dec 18, 2007·Nature Neuroscience·Armen C ArevianNathaniel N Urban

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