Combinatorial design of biomaterials for drug delivery: opportunities and challenges

Expert Opinion on Drug Delivery
L K Petersen, Balaji Narasimhan

Abstract

The rational design of biodegradable polymeric devices for controlled drug delivery and tissue engineering is an important area of research for advancing new therapies for cancer, diabetes and immune-related disorders. In an era of escalating costs for discovery-based research, there is an urgent need to develop new and rapid methods to design drug delivery systems. By merging this field of study with rapid and high throughput methods of design, optimization and development, researchers have been able to accelerate the discovery and design processes for these devices. Combinatorial research enables the rapid identification of key regions of interest. This review focuses on the opportunities and challenges in the area of combinatorial biomaterials design for drug delivery, as there has been a great deal of significant progress over the past decade to propel this approach for the rational design of biomaterials.

References

Jan 1, 1992·Journal of Biomaterials Science. Polymer Edition·J Tamada, R Langer
Nov 1, 1995·Journal of Biomedical Materials Research·T G RuardyH J Busscher
Sep 18, 1998·Journal of Biomedical Materials Research·S BrocchiniJ Kohn
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·R A Houghten
Feb 24, 2001·Biomaterials·E ShenB Narasimhan
Dec 6, 2001·Advanced Drug Delivery Reviews·S Brocchini
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Elizabeth ShenBalaji Narasimhan
May 2, 2003·Journal of the American Chemical Society·Akin AkincRobert Langer
Jul 31, 2003·Journal of Biomedical Materials Research. Part a·Tithi Dutta RoyJ Russell Parsons
Aug 15, 2003·Journal of Biomedical Materials Research. Part a·J Carson MeredithEric J Amis
Jun 15, 2004·Nature Biotechnology·Daniel G AndersonRobert Langer
Oct 20, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amy S DetermanBalaji Narasimhan
Nov 2, 2004·Nature Materials·Joachim Kohn
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniel G AndersonJanet A Sawicki
Dec 14, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jenny RickerbySteve Brocchini
Feb 25, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel G AndersonRobert Langer
Mar 15, 2005·Biomaterials·Daniel G AndersonRobert Langer
Jul 1, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Jason A BurdickRobert Langer
Aug 25, 2005·Biomaterials·Brendan A HarleyAlessandro Sannino
Sep 3, 2005·Journal of Biomedical Materials Research. Part a·María P TorresSurya K Mallapragada
Nov 15, 2005·Journal of Combinatorial Chemistry·Brandon M VogelSurya K Mallapragada
Dec 14, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Ying MeiNewell R Washburn
Dec 14, 2005·Journal of Biomedical Materials Research. Part a·Matt J KipperBalaji Narasimhan
Sep 13, 2006·Biomaterials·María P TorresBalaji Narasimhan
Feb 24, 2007·Nature Neuroscience·Kalyani Narasimhan
Aug 4, 2007·The Review of Scientific Instruments·Carl G SimonMatthew L Becker
Jan 29, 2008·Combinatorial Chemistry & High Throughput Screening·Annette AdlerH Ulrich Göringer
May 7, 2008·Biomedical Materials·Chen ChenZhongze Gu

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Citations

May 24, 2011·Tissue Engineering. Part a·Latrisha K PetersenBalaji Narasimhan
Apr 15, 2010·Acta Biomaterialia·L K PetersenB Narasimhan
Oct 6, 2009·Advanced Drug Delivery Reviews·Narayan BhattaraiMiqin Zhang
Apr 5, 2018·ACS Combinatorial Science·Jonathan T GoodmanBalaji Narasimhan

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